Does Rhonda Patrick recommend Glycine?
Rhonda Patrick recommends Glycine in some contexts, but has also raised cautions.
Published research rates it moderate evidence. Of Rhonda Patrick's 104 tracked claims, 26 are supported or partially supported by studies on PubMed.
Evidence last reviewed May 2026
Rhonda Patrick on Glycine — 104 claims
“Bone broth and collagen peptide supplements are glycine-rich foods, but supplemental glycine at 3 to 10 grams per day is an alternative.”
Supplemental glycine at 3 to 10 grams per day is an alternative to bone broth and collagen peptide supplements for supporting collagen synthesis.
The claim that glycine supplementation supports collagen synthesis has biological plausibility supported by the included literature. The glycine review (PMID: 28337245) discusses its multifarious bene…
“Bone broth and collagen peptide supplements are glycine-rich foods, but supplemental glycine at 3 to 10 grams per day is an alternative.”
Supplemental glycine at 3 to 10 grams per day is an alternative to bone broth and collagen peptide supplements for supporting collagen synthesis.
The available research does not directly address the claim that supplemental glycine at 3–10 grams per day serves as an alternative to bone broth or collagen peptides for collagen synthesis support. P…
“Bone broth and collagen peptide supplements are glycine-rich foods, but supplemental glycine at 3 to 10 grams per day is an alternative.”
Supplemental glycine at 3 to 10 grams per day is an alternative to bone broth and collagen peptide supplements for supporting collagen synthesis.
The provided research corpus does not contain studies that directly evaluate supplemental glycine as an alternative to bone broth or collagen peptides for collagen synthesis support. While PMID 378513…
“Bone broth and collagen peptide supplements are glycine-rich foods, but supplemental glycine at 3 to 10 grams per day is an alternative.”
Supplemental glycine at 3 to 10 grams per day is an alternative to bone broth and collagen peptide supplements for supporting collagen synthesis.
None of the provided studies directly test supplemental glycine (3–10 g/day) as a substitute for bone broth or collagen peptides in supporting collagen synthesis. The most relevant study (PMID 2785261…
“The dose studied is 3 grams taken 30 to 60 minutes before sleep.”
The recommended dose of glycine for sleep is 3 grams taken 30 to 60 minutes before sleep.
None of the 10 published research studies provided directly investigate glycine supplementation for sleep, nor do they address the specific dosing recommendation of 3 grams taken 30–60 minutes before…
“Bone broth and collagen peptide supplements are glycine-rich foods, but supplemental glycine at 3 to 10 grams per day is an alternative.”
Supplemental glycine at 3 to 10 grams per day is an alternative to bone broth and collagen peptide supplements for supporting collagen synthesis.
The claim that glycine supplementation supports collagen synthesis has biological plausibility supported by the glycine review literature (PMIDs 37510995, 28337245), as glycine is a primary amino acid…
“The dose studied is 3 grams taken 30 to 60 minutes before sleep.”
The recommended dose of glycine for sleep is 3 grams taken 30 to 60 minutes before sleep.
None of the 10 listed studies specifically examine glycine supplementation for sleep, the 3-gram dose, or the 30-to-60-minute pre-sleep timing window. While two reviews (PMIDs 37510995 and 28337245) d…
“The dose studied is 3 grams taken 30 to 60 minutes before sleep.”
The recommended dose of glycine for sleep is 3 grams taken 30 to 60 minutes before sleep.
None of the 10 provided studies directly examine glycine supplementation for sleep outcomes, dosing protocols, or timing recommendations. The most relevant study (PMID: 37851316) is a systematic revie…
“The dose studied is 3 grams taken 30 to 60 minutes before sleep.”
The recommended dose of glycine for sleep is 3 grams taken 30 to 60 minutes before sleep.
None of the 10 provided studies directly examine glycine supplementation for sleep outcomes, dosing protocols, or timing recommendations. The most potentially relevant study (PMID: 37851316) is a syst…
“The dose studied is 3 grams taken 30 to 60 minutes before sleep.”
The recommended dose of glycine for sleep is 3 grams taken 30 to 60 minutes before sleep.
None of the 10 published research sources listed address glycine supplementation for sleep, specific dosing for sleep, or the 30-60 minute pre-sleep timing recommendation. While glycine's anti-inflamm…
“Bone broth and collagen peptide supplements are glycine-rich foods, but supplemental glycine at 3 to 10 grams per day is an alternative.”
Supplemental glycine at 3 to 10 grams per day is an alternative to bone broth and collagen peptide supplements for supporting collagen synthesis.
Several studies in the provided list offer indirect support for the claim. The RCT on GlyNAC supplementation (PMID: 35975308) demonstrates that supplemental glycine has measurable biological effects i…
“The dose studied is 3 grams taken 30 to 60 minutes before sleep.”
The recommended dose of glycine for sleep is 3 grams taken 30 to 60 minutes before sleep.
None of the 10 provided research papers directly address glycine supplementation for sleep, nor do any examine the specific dose (3 grams) or timing (30–60 minutes before sleep) cited in the expert's…
“The dose studied is 3 grams taken 30 to 60 minutes before sleep.”
The recommended dose of glycine for sleep is 3 grams taken 30 to 60 minutes before sleep.
None of the 10 provided studies directly investigate glycine supplementation for sleep quality, dosing, or timing. The retrieved literature covers unrelated topics such as GlyNAC for aging, glycine as…
“Bone broth and collagen peptide supplements are glycine-rich foods, but supplemental glycine at 3 to 10 grams per day is an alternative.”
Supplemental glycine at 3 to 10 grams per day is an alternative to bone broth and collagen peptide supplements for supporting collagen synthesis.
None of the provided studies directly test supplemental glycine (3–10 g/day) as an alternative to bone broth or collagen peptides for collagen synthesis. The most relevant study (PMID 27852613) examin…
“Bone broth and collagen peptide supplements are glycine-rich foods, but supplemental glycine at 3 to 10 grams per day is an alternative.”
Supplemental glycine at 3 to 10 grams per day is an alternative to bone broth and collagen peptide supplements for supporting collagen synthesis.
None of the provided studies directly evaluate supplemental glycine (3–10 g/day) as an alternative to bone broth or collagen peptide supplements for collagen synthesis support. PMID 37851316, a system…
“The dose studied is 3 grams taken 30 to 60 minutes before sleep.”
The recommended dose of glycine for sleep is 3 grams taken 30 to 60 minutes before sleep.
None of the 10 provided studies directly examine glycine supplementation for sleep quality, dosing protocols, or timing recommendations. The retrieved literature covers tangentially related topics suc…
“There's actually a clinical trial by Kumar et al. showing that supplementing with glycine and N-acetylcysteine in older adults significantly restored glutathione levels and improved several markers of oxidative stress and mitochondrial function.”
A clinical trial by Kumar et al. showed that supplementing with glycine and N-acetylcysteine in older adults significantly restored glutathione levels and improved markers of oxidative stress and mitochondrial function.
The expert's claim directly aligns with PMID 35975308, an RCT titled 'Supplementing Glycine and N-Acetylcysteine (GlyNAC) in Older Adults Improves Glutathione Deficiency, Oxidative Stress, Mitochondri…
“There's actually a clinical trial by Kumar et al. showing that supplementing with glycine and N-acetylcysteine in older adults significantly restored glutathione levels and improved several markers of oxidative stress and mitochondrial function.”
A clinical trial by Kumar et al. showed that supplementing with glycine and N-acetylcysteine in older adults significantly restored glutathione levels and improved markers of oxidative stress and mitochondrial function.
The expert's claim is directly supported by PMID 35975308, an RCT explicitly titled 'Supplementing Glycine and N-Acetylcysteine (GlyNAC) in Older Adults Improves Glutathione Deficiency, Oxidative Stre…
“A 2019 paper by Ables and colleagues showed that adding glycine to a high-methionine diet in mice produced similar longevity outcomes to methionine restriction itself.”
A 2019 paper by Ables and colleagues showed that adding glycine to a high-methionine diet in mice produced similar longevity outcomes to methionine restriction itself.
The expert's claim specifically references a 2019 paper by Ables and colleagues demonstrating that glycine supplementation in a high-methionine mouse diet mimics methionine restriction longevity outco…
“This was a randomized crossover study that gave 3 grams of glycine before bed to healthy volunteers and measured sleep architecture via polysomnography. The glycine group showed significant increases in slow-wave sleep — stage 3 non-REM sleep — and reductions in next-day fatigue and sleepiness.”
The Bannai et al. 2012 randomized crossover study found that 3 grams of glycine taken before bed significantly increased slow-wave sleep and reduced next-day fatigue and sleepiness in healthy volunteers.
The expert specifically cites the Bannai et al. 2012 study on glycine and sleep, but this study does not appear in any of the 10 provided PubMed references. None of the listed studies address glycine'…
Other supplements Rhonda Patrick discusses
Claims are extracted from publicly available podcasts and videos, attributed to their source, and compared against PubMed research. This is educational information only — consult a healthcare provider before starting any supplement.
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