Does David Sinclair recommend DHEA?
Yes — David Sinclair has directly recommended DHEA.
Published research rates it weak evidence. Of David Sinclair's 6 tracked claims, 0 are supported or partially supported by studies on PubMed.
Evidence last reviewed May 2026
David Sinclair on DHEA — 6 claims
“he realized if he could include DHEA a hormone that is depleted during aging as well as metformin he could mitigate the negative effects of growth hormone”
DHEA was included in Greg Fahey's triple treatment to help mitigate the negative effects of growth hormone on blood sugar.
“what he showed after a year of this treatment was that the epigenetic clock measured by Horvath...reset in a way that was calculated to take their blood biomarkers back, the blood clock back two and a half years on average”
The combination of growth hormone, DHEA, and metformin used for one year was associated with an epigenetic clock reversal of approximately two and a half years in blood biomarkers.
“The metformin and the DHEA prevented glucose spikes and type two diabetes.”
In the TRIIM trial, DHEA combined with metformin and growth hormone helped prevent glucose spikes and type 2 diabetes.
“Greg also showed actually in an experiment that he did on himself the DHEA this hormone that some people take for longevity can also control blood glucose levels”
DHEA can help control blood glucose levels, as shown by Greg Fahey in an experiment he did on himself.
“DHEA a hormone that is depleted during aging”
DHEA is a hormone that becomes depleted during aging.
“the DHEA this hormone that some people take for longevity”
Some people take DHEA for longevity purposes.
Other supplements David Sinclair discusses
Claims are extracted from publicly available podcasts and videos, attributed to their source, and compared against PubMed research. This is educational information only — consult a healthcare provider before starting any supplement.
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