Abstraction Health

Rhodiola Rosea — Expert Claims

Extracted from publicly available podcast transcripts and videos. Each claim is attributed and sourced.

Expert Consensus

Research agrees
1/5
Experts mention
1
Recommend
1
Flag caution
Andrew Huberman
Andrew Huberman Recommends Caution
Research agrees60 claims200–400milligramsstandardized extract

Claims are extracted using AI (Claude) from publicly available transcripts, each attributed to its source with an extraction-confidence rating (high / medium / low) so it can be verified, then compared against PubMed research. See how our data is made.

Experts in this data:Andrew Huberman

60 expert mentions

Andrew Huberman
Andrew Huberman
Stanford School of Medicine / Huberman Lab
Direct recommendation

Rhodiola appears to have a stimulating effect and is generally better taken in the morning or early afternoon rather than in the evening, as it can impair sleep if taken too late.

Extracted claim

Rhodiola appears to have a stimulating effect and is generally better taken in the morning or early afternoon rather than in the evening, as it can impair sleep if taken too late.

morning or early afternoon📍 avoid evening use to prevent sleep impairment
Insufficient evidence to assessHigh confidence

None of the 10 retrieved studies provide key findings, populations, or limitations data that can be directly evaluated, making it impossible to confirm or refute Huberman's claim about Rhodiola's stim…

Andrew Huberman
Andrew Huberman
Stanford School of Medicine / Huberman Lab
Direct recommendation

The typical dose is 200 to 400 milligrams of a standardized extract per day.

Extracted claim

The typical recommended dose of Rhodiola is 200 to 400 milligrams of a standardized extract per day.

200–400 milligramsstandardized extractdaily📍 200 to 400 mg of standardized extract per day
Insufficient evidence to assessHigh confidence

None of the 20 publications listed provide explicit dosing recommendations for Rhodiola rosea in the 200–400 mg/day range. While several RCTs and systematic reviews (e.g., PMID 37495266, PMID 39601362…

Andrew Huberman
Andrew Huberman
Stanford School of Medicine / Huberman Lab
Direct recommendation

The typical dose is 200 to 400 milligrams of a standardized extract per day.

Extracted claim

The typical dose of Rhodiola is 200 to 400 milligrams of a standardized extract per day.

200–400 milligramsstandardized extractdaily📍 typical daily dose
Insufficient evidence to assessHigh confidence

While the published research list includes potentially relevant studies (a systematic review of Rhodiola RCTs, WFSBP/CANMAT clinical guidelines, and several RCTs), none of the provided records include…

Andrew Huberman
Andrew Huberman
Stanford School of Medicine / Huberman Lab
Direct recommendation

Rhodiola appears to have a stimulating effect and is generally better taken in the morning or early afternoon rather than in the evening, as it can impair sleep if taken too late.

Extracted claim

Rhodiola appears to have a stimulating effect and is generally better taken in the morning or early afternoon rather than in the evening, as it can impair sleep if taken too late.

morning or early afternoon📍 avoid evening use to prevent sleep impairment
Insufficient evidence to assessHigh confidence

None of the 10 provided studies contain extractable key findings (all show 'None' for key findings, populations, and limitations), making it impossible to directly evaluate Huberman's claim about Rhod…

Andrew Huberman
Andrew Huberman
Stanford School of Medicine / Huberman Lab
Direct recommendation

The typical dose is 200 to 400 milligrams of a standardized extract per day.

Extracted claim

The typical dose of Rhodiola is 200 to 400 milligrams of a standardized extract per day.

200–400 milligramsstandardized extractdaily📍 typical daily dose
Insufficient evidence to assessHigh confidence

While the provided literature includes relevant studies on Rhodiola rosea (including a strong-quality systematic review, PMID 37495266, and WFSBP/CANMAT clinical guidelines, PMID 35311615), none of th…

Andrew Huberman
Andrew Huberman
Stanford School of Medicine / Huberman Lab
Direct recommendation

Rhodiola appears to have a stimulating effect and is generally better taken in the morning or early afternoon rather than in the evening, as it can impair sleep if taken too late.

Extracted claim

Rhodiola appears to have a stimulating effect and is generally better taken in the morning or early afternoon rather than in the evening, as it can impair sleep if taken too late.

morning or early afternoon📍 avoid evening use to prevent sleep impairment
Insufficient evidence to assessHigh confidence

None of the 10 published studies provided contain key findings or data that directly address Rhodiola's stimulating properties or its effects on sleep timing. While the study list includes relevant st…

Andrew Huberman
Andrew Huberman
Stanford School of Medicine / Huberman Lab
Direct recommendation

Rhodiola appears to have a stimulating effect and is generally better taken in the morning or early afternoon rather than in the evening, as it can impair sleep if taken too late.

Extracted claim

Rhodiola appears to have a stimulating effect and is generally better taken in the morning or early afternoon rather than in the evening, as it can impair sleep if taken too late.

morning or early afternoon📍 avoid evening use to prevent sleep impairment
Insufficient evidence to assessHigh confidence

None of the 20 listed studies directly examine the timing of Rhodiola rosea supplementation in relation to sleep outcomes or test whether evening use impairs sleep quality. The narrative review on die…

Andrew Huberman
Andrew Huberman
Stanford School of Medicine / Huberman Lab
Direct recommendation

Rhodiola appears to have a stimulating effect and is generally better taken in the morning or early afternoon rather than in the evening, as it can impair sleep if taken too late.

Extracted claim

Rhodiola appears to have a stimulating effect and is generally better taken in the morning or early afternoon rather than in the evening, as it can impair sleep if taken too late.

morning or early afternoon📍 avoid evening use to prevent sleep impairment
Insufficient evidence to assessHigh confidence

None of the 10 retrieved studies provide key findings, populations, or limitations data, making it impossible to directly evaluate Huberman's claim that Rhodiola has a stimulating effect that can impa…

Andrew Huberman
Andrew Huberman
Stanford School of Medicine / Huberman Lab
Direct recommendation

The typical dose is 200 to 400 milligrams of a standardized extract per day.

Extracted claim

The typical dose of Rhodiola is 200 to 400 milligrams of a standardized extract per day.

200–400 milligramsstandardized extractdaily📍 typical daily dose
Partially supportedHigh confidence

The provided literature does not directly state that 200–400 mg/day is the standard dose for Rhodiola rosea supplementation. However, the systematic review (PMID: 37495266) on Rhodiola supplementation…

Andrew Huberman
Andrew Huberman
Stanford School of Medicine / Huberman Lab
Direct recommendation

Rhodiola appears to have a stimulating effect and is generally better taken in the morning or early afternoon rather than in the evening, as it can impair sleep if taken too late.

Extracted claim

Rhodiola has a stimulating effect and should be taken in the morning or early afternoon, not in the evening, as it can impair sleep if taken too late.

morning or early afternoon📍 avoid evening use due to stimulating effect that can impair sleep
Insufficient evidence to assessHigh confidence

None of the 20 listed studies directly examine the timing of Rhodiola rosea supplementation relative to sleep quality or provide evidence that evening dosing impairs sleep. The available research (inc…

Andrew Huberman
Andrew Huberman
Stanford School of Medicine / Huberman Lab
Direct recommendation

The typical dose is 200 to 400 milligrams of a standardized extract per day.

Extracted claim

The typical dose of Rhodiola is 200 to 400 milligrams of a standardized extract per day.

200–400 milligramsstandardized extractdaily📍 typical daily dose
Insufficient evidence to assessHigh confidence

While the provided research list includes potentially relevant studies (e.g., PMID 37495266, a strong-quality systematic review on Rhodiola rosea and sports performance, and PMID 35311615, strong-qual…

Andrew Huberman
Andrew Huberman
Stanford School of Medicine / Huberman Lab
Direct recommendation

The typical dose is 200 to 400 milligrams of a standardized extract per day.

Extracted claim

The typical dose of Rhodiola is 200 to 400 milligrams of a standardized extract per day.

200–400 milligramsstandardized extractdaily📍 typical daily dose
Insufficient evidence to assessHigh confidence

None of the 10 retrieved studies provide extractable key findings, populations, or dosing details that directly confirm or refute the claimed 200–400 mg/day range for standardized Rhodiola rosea extra…

Andrew Huberman
Andrew Huberman
Stanford School of Medicine / Huberman Lab
Evidence-backed claim

Multiple trials have shown that Rhodiola reduces mental fatigue in physicians on night shifts, students during exam periods, and military cadets under sleep deprivation. The effect size is moderate but reproducible — typically around a 20 to 30 percent improvement in cognitive performance metrics.

Extracted claim

Multiple trials have shown that Rhodiola reduces mental fatigue in physicians on night shifts, students during exam periods, and military cadets under sleep deprivation, with approximately 20–30% improvement in cognitive performance metrics.

Partially supportedHigh confidence

The research base includes a systematic review (PMID 37495266, rated strong quality) on Rhodiola rosea and physical/cognitive performance, a strong-quality meta-analysis on nutraceuticals for psychiat…

Andrew Huberman
Andrew Huberman
Stanford School of Medicine / Huberman Lab
Evidence-backed claim

One well-designed study compared Rhodiola to sertraline — an SSRI — for mild to moderate depression and found comparable effects on depressive symptoms with fewer side effects.

Extracted claim

A well-designed study compared Rhodiola to sertraline for mild to moderate depression and found comparable effects on depressive symptoms with fewer side effects.

Insufficient evidence to assessHigh confidence

None of the 10 provided studies directly examine Rhodiola rosea compared to sertraline for mild to moderate depression. The retrieved literature focuses predominantly on athletic performance, exercise…

Andrew Huberman
Andrew Huberman
Stanford School of Medicine / Huberman Lab
Evidence-backed claim

the adaptogen category has a lot of marketing hype around it, but Rhodiola is one of the better-studied members of this category and I think the evidence is worth taking seriously.

Extracted claim

The adaptogen category has a lot of marketing hype, but Rhodiola is one of the better-studied members and the evidence is worth taking seriously.

Partially supportedHigh confidence

The claim that Rhodiola is 'better-studied' among adaptogens and worth taking seriously is partially supported by the breadth of study designs present in the retrieved literature, which includes multi…

Andrew Huberman
Andrew Huberman
Stanford School of Medicine / Huberman Lab
Evidence-backed claim

Multiple trials have shown that Rhodiola reduces mental fatigue in physicians on night shifts, students during exam periods, and military cadets under sleep deprivation. The effect size is moderate but reproducible — typically around a 20 to 30 percent improvement in cognitive performance metrics.

Extracted claim

Multiple trials have shown that Rhodiola reduces mental fatigue in physicians on night shifts, students during exam periods, and military cadets under sleep deprivation, with a typical improvement of 20 to 30 percent in cognitive performance metrics.

Insufficient evidence to assessHigh confidence

None of the 10 retrieved studies directly address the specific populations cited in Huberman's claim (physicians on night shifts, students during exam periods, or military cadets under sleep deprivati…

Andrew Huberman
Andrew Huberman
Stanford School of Medicine / Huberman Lab
Evidence-backed claim

the adaptogen category has a lot of marketing hype around it, but Rhodiola is one of the better-studied members of this category and I think the evidence is worth taking seriously.

Extracted claim

The adaptogen category has a lot of marketing hype, but Rhodiola is one of the better-studied members and the evidence is worth taking seriously.

Partially supportedHigh confidence

The expert's claim that Rhodiola is 'better-studied' among adaptogens and that its evidence is 'worth taking seriously' is partially supported by the research corpus. The presence of a strong-quality…

Andrew Huberman
Andrew Huberman
Stanford School of Medicine / Huberman Lab
Evidence-backed claim

One well-designed study compared Rhodiola to sertraline — an SSRI — for mild to moderate depression and found comparable effects on depressive symptoms with fewer side effects.

Extracted claim

A well-designed study compared Rhodiola to sertraline for mild to moderate depression and found comparable effects on depressive symptoms with fewer side effects.

Insufficient evidence to assessHigh confidence

None of the 10 retrieved studies directly address a comparison between Rhodiola rosea and sertraline for mild to moderate depression. The retrieved literature focuses primarily on sports performance,…

Andrew Huberman
Andrew Huberman
Stanford School of Medicine / Huberman Lab
Evidence-backed claim

the adaptogen category has a lot of marketing hype around it, but Rhodiola is one of the better-studied members of this category and I think the evidence is worth taking seriously.

Extracted claim

The adaptogen category has a lot of marketing hype, but Rhodiola is one of the better-studied members and the evidence is worth taking seriously.

Partially supportedHigh confidence

The claim that Rhodiola is 'better-studied' among adaptogens and that its evidence is 'worth taking seriously' receives partial support from the literature provided. The presence of a strong-quality s…

Andrew Huberman
Andrew Huberman
Stanford School of Medicine / Huberman Lab
Evidence-backed claim

the adaptogen category has a lot of marketing hype around it, but Rhodiola is one of the better-studied members of this category and I think the evidence is worth taking seriously.

Extracted claim

The adaptogen category has a lot of marketing hype, but Rhodiola is one of the better-studied members and the evidence is worth taking seriously.

Partially supportedHigh confidence

The claim that Rhodiola is among the better-studied adaptogens with evidence worth taking seriously receives partial support from the available literature. The presence of a strong-quality systematic…

Andrew Huberman
Andrew Huberman
Stanford School of Medicine / Huberman Lab
Evidence-backed claim

One well-designed study compared Rhodiola to sertraline — an SSRI — for mild to moderate depression and found comparable effects on depressive symptoms with fewer side effects.

Extracted claim

A well-designed study compared Rhodiola to sertraline for mild to moderate depression and found comparable effects on depressive symptoms with fewer side effects.

Insufficient evidence to assessHigh confidence

None of the 10 retrieved studies directly address a head-to-head comparison of Rhodiola rosea versus sertraline for mild-to-moderate depression. The provided literature focuses primarily on sports per…

Andrew Huberman
Andrew Huberman
Stanford School of Medicine / Huberman Lab
Evidence-backed claim

Multiple trials have shown that Rhodiola reduces mental fatigue in physicians on night shifts, students during exam periods, and military cadets under sleep deprivation. The effect size is moderate but reproducible — typically around a 20 to 30 percent improvement in cognitive performance metrics.

Extracted claim

Multiple trials have shown that Rhodiola reduces mental fatigue in physicians on night shifts, students during exam periods, and military cadets under sleep deprivation, with a typical improvement of 20 to 30 percent in cognitive performance metrics.

Insufficient evidence to assessHigh confidence

The 10 retrieved studies do not provide usable key findings, populations, or limitations data to directly evaluate Huberman's specific claim about Rhodiola reducing mental fatigue in physicians on nig…

Andrew Huberman
Andrew Huberman
Stanford School of Medicine / Huberman Lab
Evidence-backed claim

Multiple trials have shown that Rhodiola reduces mental fatigue in physicians on night shifts, students during exam periods, and military cadets under sleep deprivation. The effect size is moderate but reproducible — typically around a 20 to 30 percent improvement in cognitive performance metrics.

Extracted claim

Multiple trials have shown that Rhodiola reduces mental fatigue in physicians on night shifts, students during exam periods, and military cadets under sleep deprivation, with a typical improvement of 20 to 30 percent in cognitive performance metrics.

Insufficient evidence to assessHigh confidence

None of the 10 retrieved studies provide extractable key findings, populations, or limitations data, making direct comparison impossible. The studies listed include reviews and RCTs tangentially relat…

Andrew Huberman
Andrew Huberman
Stanford School of Medicine / Huberman Lab
Evidence-backed claim

One well-designed study compared Rhodiola to sertraline — an SSRI — for mild to moderate depression and found comparable effects on depressive symptoms with fewer side effects.

Extracted claim

A well-designed study compared Rhodiola to sertraline for mild to moderate depression and found comparable effects on depressive symptoms with fewer side effects.

Insufficient evidence to assessHigh confidence

None of the 10 retrieved studies directly address a comparison between Rhodiola rosea and sertraline for mild to moderate depression. The retrieved literature focuses primarily on sports performance,…

Andrew Huberman
Andrew Huberman
Stanford School of Medicine / Huberman Lab
Evidence-backed claim

Multiple trials have shown that Rhodiola reduces mental fatigue in physicians on night shifts, students during exam periods, and military cadets under sleep deprivation. The effect size is moderate but reproducible — typically around a 20 to 30 percent improvement in cognitive performance metrics.

Extracted claim

Multiple trials have shown that Rhodiola reduces mental fatigue in physicians on night shifts, students during exam periods, and military cadets under sleep deprivation, with a typical improvement of 20 to 30 percent in cognitive performance metrics.

Insufficient evidence to assessHigh confidence

The provided PubMed abstracts contain no extractable key findings, populations, or limitations data, making it impossible to directly verify or refute Huberman's specific claim. While the literature l…

Andrew Huberman
Andrew Huberman
Stanford School of Medicine / Huberman Lab
Evidence-backed claim

One well-designed study compared Rhodiola to sertraline — an SSRI — for mild to moderate depression and found comparable effects on depressive symptoms with fewer side effects. I want to be careful here because depression is a serious medical condition, and I'm not recommending Rhodiola as a primary treatment.

Extracted claim

A well-designed study found Rhodiola had comparable effects to sertraline (an SSRI) on depressive symptoms with fewer side effects, though Huberman is not recommending it as a primary treatment for depression.

Insufficient evidence to assessHigh confidence

None of the 20 listed studies directly compare Rhodiola rosea to sertraline or any other SSRI for depressive symptoms. The WFSBP/CANMAT meta-analysis (PMID: 35311615) and the mild depression meta-anal…

Andrew Huberman
Andrew Huberman
Stanford School of Medicine / Huberman Lab
Evidence-backed claim

Multiple trials have shown that Rhodiola reduces mental fatigue in physicians on night shifts, students during exam periods, and military cadets under sleep deprivation. The effect size is moderate but reproducible — typically around a 20 to 30 percent improvement in cognitive performance metrics.

Extracted claim

Multiple trials have shown that Rhodiola reduces mental fatigue in physicians on night shifts, students during exam periods, and military cadets under sleep deprivation, with a typical improvement of 20 to 30 percent in cognitive performance metrics.

Partially supportedHigh confidence

The general claim that Rhodiola rosea reduces mental and physical fatigue is broadly supported by several reviews and RCTs in the provided literature, including a systematic review (PMID: 37495266) on…

Andrew Huberman
Andrew Huberman
Stanford School of Medicine / Huberman Lab
Evidence-backed claim

One well-designed study compared Rhodiola to sertraline — an SSRI — for mild to moderate depression and found comparable effects on depressive symptoms with fewer side effects.

Extracted claim

A well-designed study compared Rhodiola to sertraline for mild to moderate depression and found comparable effects on depressive symptoms with fewer side effects.

Insufficient evidence to assessHigh confidence

None of the 20 studies provided include a head-to-head comparison of Rhodiola rosea versus sertraline for mild to moderate depression. The closest relevant studies are PMID 40014460, a meta-analysis o…

Andrew Huberman
Andrew Huberman
Stanford School of Medicine / Huberman Lab
Evidence-backed claim

the adaptogen category has a lot of marketing hype around it, but Rhodiola is one of the better-studied members of this category and I think the evidence is worth taking seriously.

Extracted claim

The adaptogen category has a lot of marketing hype, but Rhodiola is one of the better-studied members and the evidence is worth taking seriously.

Partially supportedHigh confidence

The claim that Rhodiola is better-studied than most adaptogens is supported by the breadth of research in the provided literature, including a dedicated systematic review of RCTs on sports performance…

Andrew Huberman
Andrew Huberman
Stanford School of Medicine / Huberman Lab
Evidence-backed claim

I want to be upfront that the adaptogen category has a lot of marketing hype around it, but Rhodiola is one of the better-studied members of this category and I think the evidence is worth taking seriously.

Extracted claim

The adaptogen category has a lot of marketing hype, but Rhodiola is one of the better-studied members and its evidence is worth taking seriously.

Partially supportedHigh confidence

The claim that Rhodiola is better-studied than most adaptogens and worth taking seriously is supported by the breadth of research identified, including a dedicated systematic review of RCTs (PMID: 374…

Andrew Huberman
Andrew Huberman
Stanford School of Medicine / Huberman Lab
Evidence-backed claim

One well-designed study compared Rhodiola to sertraline — an SSRI — for mild to moderate depression and found comparable effects on depressive symptoms with fewer side effects.

Extracted claim

One well-designed study found Rhodiola had comparable effects to sertraline (an SSRI) on depressive symptoms in mild to moderate depression, with fewer side effects.

Insufficient evidence to assessHigh confidence

None of the 20 provided studies directly evaluate or mention a head-to-head comparison of Rhodiola rosea against sertraline (or any SSRI) for depressive symptoms. The closest relevant sources are the…

Andrew Huberman
Andrew Huberman
Stanford School of Medicine / Huberman Lab
Evidence-backed claim

Multiple trials have shown that Rhodiola reduces mental fatigue in physicians on night shifts, students during exam periods, and military cadets under sleep deprivation. The effect size is moderate but reproducible — typically around a 20 to 30 percent improvement in cognitive performance metrics.

Extracted claim

Multiple trials have shown Rhodiola reduces mental fatigue in physicians on night shifts, students during exam periods, and military cadets under sleep deprivation, with a typical 20–30% improvement in cognitive performance metrics.

Partially supportedHigh confidence

The broader claim that Rhodiola reduces mental fatigue is plausible and directionally supported: PMID 20211986 specifically mentions Rhodiola for stress-related fatigue, and PMID 33650944 (systematic…

Andrew Huberman
Andrew Huberman
Stanford School of Medicine / Huberman Lab
Evidence-backed claim

The best evidence for Rhodiola is in the context of stress-induced fatigue and cognitive performance under stress.

Extracted claim

The best evidence for Rhodiola is in reducing stress-induced fatigue and improving cognitive performance under stress.

Partially supportedHigh confidence

Multiple studies in the provided literature support Rhodiola's role in stress-related fatigue and performance, including a review specifically noting Rhodiola's use 'against stress-related fatigue' (P…

Andrew Huberman
Andrew Huberman
Stanford School of Medicine / Huberman Lab
Mechanism discussion

The active compounds in Rhodiola are rosavins and salidroside, and most quality supplements are standardized to contain specific percentages of these compounds — typically 3% rosavins and 1% salidroside, which is considered the traditional ratio.

Extracted claim

The active compounds in Rhodiola are rosavins and salidroside, and quality supplements are typically standardized to 3% rosavins and 1% salidroside, which is considered the traditional ratio.

standardized extract📍 standardization ratio of active compounds
Partially supportedHigh confidence

The research evidence confirms that rosavins and salidroside are recognized as key active constituents of Rhodiola rosea, as referenced across multiple studies including PMID 39601362 (salidroside RCT…

Andrew Huberman
Andrew Huberman
Stanford School of Medicine / Huberman Lab
Mechanism discussion

The active compounds in Rhodiola are rosavins and salidroside, and most quality supplements are standardized to contain specific percentages of these compounds — typically 3% rosavins and 1% salidroside, which is considered the traditional ratio.

Extracted claim

The active compounds in Rhodiola are rosavins and salidroside, and quality supplements are typically standardized to 3% rosavins and 1% salidroside.

Partially supportedHigh confidence

The published research confirms that rosavins and salidroside are recognized as key active constituents of Rhodiola rosea. PMID 39601362 specifically identifies salidroside as 'one of the main constit…

Andrew Huberman
Andrew Huberman
Stanford School of Medicine / Huberman Lab
Mechanism discussion

The active compounds in Rhodiola are rosavins and salidroside, and most quality supplements are standardized to contain specific percentages of these compounds — typically 3% rosavins and 1% salidroside, which is considered the traditional ratio.

Extracted claim

The active compounds in Rhodiola are rosavins and salidroside, and quality supplements are typically standardized to 3% rosavins and 1% salidroside, which is considered the traditional ratio.

standardized extract📍 standardization ratio of active compounds
Insufficient evidence to assessHigh confidence

The expert's claim concerns the identity of active compounds in Rhodiola rosea (rosavins and salidroside) and the standardized ratios used in commercial supplements (3% rosavins, 1% salidroside). None…

Andrew Huberman
Andrew Huberman
Stanford School of Medicine / Huberman Lab
Mechanism discussion

The active compounds in Rhodiola are rosavins and salidroside, and most quality supplements are standardized to contain specific percentages of these compounds — typically 3% rosavins and 1% salidroside, which is considered the traditional ratio.

Extracted claim

The active compounds in Rhodiola are rosavins and salidroside, and quality supplements are typically standardized to 3% rosavins and 1% salidroside, which is considered the traditional ratio.

standardized extract📍 standardization ratio of active compounds
Insufficient evidence to assessHigh confidence

The expert's claim about rosavins and salidroside as active compounds and the 3%/1% standardization ratio is a widely cited industry and pharmacognosy convention, but none of the 10 provided studies c…

Andrew Huberman
Andrew Huberman
Stanford School of Medicine / Huberman Lab
Mechanism discussion

Rhodiola rosea is an adaptogen — a class of plants that purportedly help the body resist physical and mental stress.

Extracted claim

Rhodiola rosea is an adaptogen, a class of plants that purportedly help the body resist physical and mental stress.

Partially supportedHigh confidence

The expert's claim that Rhodiola rosea is an adaptogen that helps the body resist physical and mental stress is a well-established classification in herbal medicine literature, and the available resea…

Andrew Huberman
Andrew Huberman
Stanford School of Medicine / Huberman Lab
Mechanism discussion

it's intriguing that an adaptogen might have genuine effects on mood and stress hormones.

Extracted claim

Rhodiola may have genuine effects on mood and stress hormones.

Partially supportedMedium confidence

Several studies in the provided literature lend indirect support to Huberman's claim. The systematic review on HPA-axis modulation (PMID 33650944, strong quality) evaluated randomized controlled trial…

Andrew Huberman
Andrew Huberman
Stanford School of Medicine / Huberman Lab
Mechanism discussion

Rhodiola rosea is an adaptogen — a class of plants that purportedly help the body resist physical and mental stress.

Extracted claim

Rhodiola rosea is an adaptogen, a class of plants that purportedly help the body resist physical and mental stress.

Partially supportedHigh confidence

The claim that Rhodiola rosea is an adaptogen that helps the body resist physical and mental stress is a widely recognized characterization in herbal medicine literature, and the presence of multiple…

Andrew Huberman
Andrew Huberman
Stanford School of Medicine / Huberman Lab
Mechanism discussion

The active compounds in Rhodiola are rosavins and salidroside, and most quality supplements are standardized to contain specific percentages of these compounds — typically 3% rosavins and 1% salidroside, which is considered the traditional ratio.

Extracted claim

The active compounds in Rhodiola are rosavins and salidroside, and quality supplements are typically standardized to 3% rosavins and 1% salidroside, which is considered the traditional ratio.

standardized extract📍 standardization ratio of active compounds
Insufficient evidence to assessHigh confidence

The expert's claim about rosavins and salidroside as active compounds, and the 3% rosavins/1% salidroside standardization ratio, is a commonly cited industry and phytochemical standard, but none of th…

Andrew Huberman
Andrew Huberman
Stanford School of Medicine / Huberman Lab
Mechanism discussion

Rhodiola rosea is an adaptogen — a class of plants that purportedly help the body resist physical and mental stress.

Extracted claim

Rhodiola rosea is an adaptogen, a class of plants that purportedly help the body resist physical and mental stress.

Partially supportedHigh confidence

The expert's claim that Rhodiola rosea is an adaptogen that helps the body resist physical and mental stress is broadly consistent with the general scientific literature and is referenced across multi…

Andrew Huberman
Andrew Huberman
Stanford School of Medicine / Huberman Lab
Mechanism discussion

Rhodiola rosea is an adaptogen — a class of plants that purportedly help the body resist physical and mental stress.

Extracted claim

Rhodiola rosea is an adaptogen that purportedly helps the body resist physical and mental stress.

Supported by researchHigh confidence

Multiple sources in the provided literature directly support the claim that Rhodiola rosea is an adaptogen purported to help resist physical and mental stress. The systematic review (PMID: 37495266) s…

Andrew Huberman
Andrew Huberman
Stanford School of Medicine / Huberman Lab
Mechanism discussion

The active compounds in Rhodiola are rosavins and salidroside, and most quality supplements are standardized to contain specific percentages of these compounds — typically 3% rosavins and 1% salidroside, which is considered the traditional ratio.

Extracted claim

The active compounds in Rhodiola are rosavins and salidroside, and quality supplements are typically standardized to 3% rosavins and 1% salidroside, which is considered the traditional ratio.

standardized extract📍 standardization ratio of active compounds
Insufficient evidence to assessHigh confidence

None of the 10 provided studies directly address the specific claim about rosavins and salidroside as active compounds or the standardization ratios of 3% rosavins and 1% salidroside. While PMID 39601…

Andrew Huberman
Andrew Huberman
Stanford School of Medicine / Huberman Lab
Mechanism discussion

Rhodiola rosea is an adaptogen — a class of plants that purportedly help the body resist physical and mental stress.

Extracted claim

Rhodiola rosea is an adaptogen, a class of plants that purportedly help the body resist physical and mental stress.

Supported by researchHigh confidence

Multiple studies in the provided literature directly characterize Rhodiola rosea as an adaptogen with stress-resisting properties. The systematic review (PMID: 37495266) evaluates R. rosea supplementa…

Andrew Huberman
Andrew Huberman
Stanford School of Medicine / Huberman Lab
Mechanism discussion

Rhodiola rosea is an adaptogen — a class of plants that purportedly help the body resist physical and mental stress.

Extracted claim

Rhodiola rosea is an adaptogen, a class of plants that purportedly help the body resist physical and mental stress.

Partially supportedHigh confidence

The expert's characterization of Rhodiola rosea as an adaptogen that helps the body resist physical and mental stress is consistent with the general framing seen across multiple study types in the pro…

Andrew Huberman
Andrew Huberman
Stanford School of Medicine / Huberman Lab
Caution / warning

I want to be careful here because depression is a serious medical condition, and I'm not recommending Rhodiola as a primary treatment. But it's intriguing that an adaptogen might have genuine effects on mood and stress hormones.

Extracted claim

Huberman notes it is intriguing that an adaptogen might have genuine effects on mood and stress hormones, while cautioning he is not recommending Rhodiola as a primary treatment for depression.

Insufficient evidence to assessHigh confidence

None of the 10 provided studies directly examine Rhodiola rosea's effects on mood or stress hormones (e.g., cortisol) in the context of depression treatment. The available studies focus primarily on e…

Andrew Huberman
Andrew Huberman
Stanford School of Medicine / Huberman Lab
Caution / warning

I want to be careful here because depression is a serious medical condition, and I'm not recommending Rhodiola as a primary treatment. But it's intriguing that an adaptogen might have genuine effects on mood and stress hormones.

Extracted claim

Huberman notes it is intriguing that an adaptogen might have genuine effects on mood and stress hormones, while cautioning he is not recommending Rhodiola as a primary treatment for depression.

Insufficient evidence to assessHigh confidence

None of the 10 retrieved studies provide extractable key findings, populations, or limitations data, making it impossible to directly evaluate Huberman's claim that Rhodiola may have genuine effects o…

Andrew Huberman
Andrew Huberman
Stanford School of Medicine / Huberman Lab
Caution / warning

I want to be careful here because depression is a serious medical condition, and I'm not recommending Rhodiola as a primary treatment. But it's intriguing that an adaptogen might have genuine effects on mood and stress hormones.

Extracted claim

Huberman notes it is intriguing that an adaptogen might have genuine effects on mood and stress hormones, while cautioning he is not recommending Rhodiola as a primary treatment for depression.

Partially supportedHigh confidence

The claim has two components: (1) that Rhodiola may have genuine effects on mood and stress hormones, and (2) that it should not be used as a primary treatment for depression. The systematic review on…

Andrew Huberman
Andrew Huberman
Stanford School of Medicine / Huberman Lab
Caution / warning

I want to be careful here because depression is a serious medical condition, and I'm not recommending Rhodiola as a primary treatment. But it's intriguing that an adaptogen might have genuine effects on mood and stress hormones.

Extracted claim

Huberman is not recommending Rhodiola as a primary treatment for depression, though notes it may have genuine effects on mood and stress hormones.

Partially supportedHigh confidence

Huberman's cautious framing — that Rhodiola is not a primary treatment for depression but may have genuine effects on mood and stress hormones — is partially supported by the available evidence. The W…

Andrew Huberman
Andrew Huberman
Stanford School of Medicine / Huberman Lab
Caution / warning

Rhodiola inhibits monoamine oxidase, which means it can interact with MAOIs and SSRIs. If you're on any psychiatric medications, discuss Rhodiola with your physician before starting it.

Extracted claim

Rhodiola inhibits monoamine oxidase and can interact with MAOIs and SSRIs; anyone on psychiatric medications should consult a physician before taking it.

Insufficient evidence to assessHigh confidence

None of the 10 retrieved studies provide direct evidence addressing Rhodiola's MAO-inhibiting properties or its pharmacological interactions with MAOIs or SSRIs. The WFSBP/CANMAT taskforce guidelines…

Andrew Huberman
Andrew Huberman
Stanford School of Medicine / Huberman Lab
Caution / warning

Rhodiola inhibits monoamine oxidase, which means it can interact with MAOIs and SSRIs. If you're on any psychiatric medications, discuss Rhodiola with your physician before starting it.

Extracted claim

Rhodiola inhibits monoamine oxidase and can interact with MAOIs and SSRIs; anyone on psychiatric medications should consult a physician before taking it.

Insufficient evidence to assessHigh confidence

None of the 10 retrieved studies directly address Rhodiola's MAO-inhibiting properties, its pharmacological interactions with MAOIs or SSRIs, or drug-herb interaction safety data. The studies focus pr…

Andrew Huberman
Andrew Huberman
Stanford School of Medicine / Huberman Lab
Caution / warning

Rhodiola inhibits monoamine oxidase, which means it can interact with MAOIs and SSRIs. If you're on any psychiatric medications, discuss Rhodiola with your physician before starting it.

Extracted claim

Rhodiola inhibits monoamine oxidase and can interact with MAOIs and SSRIs; those on psychiatric medications should consult a physician before use.

Insufficient evidence to assessHigh confidence

None of the 20 listed studies directly examine Rhodiola rosea's monoamine oxidase (MAO) inhibitory activity in humans or document clinical drug interactions with MAOIs or SSRIs. The WFSBP/CANMAT meta-…

Andrew Huberman
Andrew Huberman
Stanford School of Medicine / Huberman Lab
Caution / warning

Rhodiola inhibits monoamine oxidase, which means it can interact with MAOIs and SSRIs. If you're on any psychiatric medications, discuss Rhodiola with your physician before starting it.

Extracted claim

Rhodiola inhibits monoamine oxidase and can interact with MAOIs and SSRIs; those on psychiatric medications should consult a physician before using it.

Insufficient evidence to assessHigh confidence

None of the 20 listed studies directly examine or report on Rhodiola rosea's monoamine oxidase (MAO) inhibitory activity in humans or its pharmacological interactions with MAOIs or SSRIs. The WFSBP/CA…

Andrew Huberman
Andrew Huberman
Stanford School of Medicine / Huberman Lab
Caution / warning

I want to be careful here because depression is a serious medical condition, and I'm not recommending Rhodiola as a primary treatment. But it's intriguing that an adaptogen might have genuine effects on mood and stress hormones.

Extracted claim

Huberman notes it is intriguing that an adaptogen might have genuine effects on mood and stress hormones, while cautioning he is not recommending Rhodiola as a primary treatment for depression.

Insufficient evidence to assessHigh confidence

None of the 10 retrieved studies provide extractable key findings (all show 'None' for key findings, population, and limitations), making it impossible to directly evaluate Huberman's claim about Rhod…

Andrew Huberman
Andrew Huberman
Stanford School of Medicine / Huberman Lab
Caution / warning

I want to be careful here because depression is a serious medical condition, and I'm not recommending Rhodiola as a primary treatment. But it's intriguing that an adaptogen might have genuine effects on mood and stress hormones.

Extracted claim

Huberman notes it is intriguing that an adaptogen might have genuine effects on mood and stress hormones, while cautioning he is not recommending Rhodiola as a primary treatment for depression.

Insufficient evidence to assessHigh confidence

None of the 10 provided studies include usable key findings, populations, or limitations data, making direct comparison impossible. The WFSBP/CANMAT meta-analysis (PMID 35311615) is the most relevant…

Andrew Huberman
Andrew Huberman
Stanford School of Medicine / Huberman Lab
Caution / warning

Rhodiola inhibits monoamine oxidase, which means it can interact with MAOIs and SSRIs. If you're on any psychiatric medications, discuss Rhodiola with your physician before starting it.

Extracted claim

Rhodiola inhibits monoamine oxidase and can interact with MAOIs and SSRIs; anyone on psychiatric medications should consult a physician before taking it.

Insufficient evidence to assessHigh confidence

None of the 10 retrieved studies provide direct evidence addressing Rhodiola's MAO-inhibiting properties or its clinical drug interactions with MAOIs and SSRIs. The WFSBP/CANMAT guidelines (PMID 35311…

Andrew Huberman
Andrew Huberman
Stanford School of Medicine / Huberman Lab
Caution / warning

Rhodiola inhibits monoamine oxidase, which means it can interact with MAOIs and SSRIs. If you're on any psychiatric medications, discuss Rhodiola with your physician before starting it.

Extracted claim

Rhodiola inhibits monoamine oxidase and can interact with MAOIs and SSRIs; anyone on psychiatric medications should consult a physician before taking it.

Insufficient evidence to assessHigh confidence

None of the 10 retrieved studies directly address Rhodiola's MAO-inhibiting properties or its pharmacological interactions with MAOIs and SSRIs. The WFSBP/CANMAT guidelines (PMID 35311615) represent t…

Andrew Huberman
Andrew Huberman
Stanford School of Medicine / Huberman Lab
Caution / warning

Rhodiola inhibits monoamine oxidase, which means it can interact with MAOIs and SSRIs. If you're on any psychiatric medications, discuss Rhodiola with your physician before starting it.

Extracted claim

Rhodiola inhibits monoamine oxidase and can interact with MAOIs and SSRIs; anyone on psychiatric medications should consult a physician before taking it.

Insufficient evidence to assessHigh confidence

None of the 20 provided studies directly address Rhodiola rosea's monoamine oxidase (MAO) inhibitory activity in humans or its pharmacological interactions with MAOIs or SSRIs. The WFSBP/CANMAT guidel…

Andrew Huberman
Andrew Huberman
Stanford School of Medicine / Huberman Lab
Caution / warning

Rhodiola appears to have a stimulating effect and is generally better taken in the morning or early afternoon rather than in the evening, as it can impair sleep if taken too late.

Extracted claim

Rhodiola has a stimulating effect and should generally be taken in the morning or early afternoon, not in the evening, as it can impair sleep.

morning or early afternoon📍 Avoid evening use due to stimulating effect that can impair sleep
Insufficient evidence to assessHigh confidence

None of the 20 studies listed directly examine the timing of Rhodiola rosea supplementation (morning vs. evening) or its effects on sleep quality or sleep onset. The review by De Bock (PMID: 16948486)…