Does Andrew Huberman recommend Glycine?
Yes — Andrew Huberman has directly recommended Glycine.
Published research rates it moderate evidence. Of Andrew Huberman's 66 tracked claims, 7 are supported or partially supported by studies on PubMed.
Evidence last reviewed May 2026
Andrew Huberman on Glycine — 66 claims
“The dose that I take and that was used in that study is 3 grams about 30 minutes before bed. Glycine is cheap, has essentially no side effects at this dose, and it tastes slightly sweet, which makes it easy to dissolve in water and drink.”
Huberman recommends 3 grams of glycine taken about 30 minutes before bed for sleep, noting it is cheap, has essentially no side effects at this dose, and can be dissolved in water due to its slightly sweet taste.
None of the 10 provided studies directly investigate glycine supplementation at 3 grams for sleep improvement, sleep onset, or sleep quality outcomes. While PMID 28337245 (a review on glycine's multif…
“The dose that I take and that was used in that study is 3 grams about 30 minutes before bed. Glycine is cheap, has essentially no side effects at this dose, and it tastes slightly sweet, which makes it easy to dissolve in water and drink.”
Huberman recommends 3 grams of glycine taken about 30 minutes before bed for sleep, noting it is cheap, has essentially no side effects at this dose, and can be dissolved in water due to its slightly sweet taste.
None of the 10 published studies listed directly evaluate glycine supplementation at 3 grams taken before bed for sleep improvement. The GlyNAC RCT (PMID: 35975308) and glycine reviews (PMIDs: 3751099…
“The dose that I take and that was used in that study is 3 grams about 30 minutes before bed. Glycine is cheap, has essentially no side effects at this dose, and it tastes slightly sweet, which makes it easy to dissolve in water and drink.”
Huberman recommends 3 grams of glycine taken about 30 minutes before bed for sleep, noting it is cheap, has essentially no side effects at this dose, and can be dissolved in water due to its slightly sweet taste.
The provided research list does not contain studies directly evaluating glycine supplementation for sleep outcomes, dosing, or timing. While PMID 37851316 (a systematic review on glycine administratio…
“The dose that I take and that was used in that study is 3 grams about 30 minutes before bed. Glycine is cheap, has essentially no side effects at this dose, and it tastes slightly sweet, which makes it easy to dissolve in water and drink.”
Huberman recommends 3 grams of glycine taken about 30 minutes before bed for sleep, noting it is cheap, has essentially no side effects at this dose, and can be dissolved in water due to its slightly sweet taste.
The provided research corpus does not contain studies directly evaluating glycine supplementation for sleep improvement. While PMID 37851316 is a systematic review on glycine administration in human a…
“The dose that I take and that was used in that study is 3 grams about 30 minutes before bed. Glycine is cheap, has essentially no side effects at this dose, and it tastes slightly sweet, which makes it easy to dissolve in water and drink.”
Huberman recommends 3 grams of glycine taken about 30 minutes before bed for sleep, noting it is cheap, has essentially no side effects at this dose, and can be dissolved in water due to its slightly sweet taste.
None of the 10 provided studies directly investigate glycine supplementation (3g or any dose) as a sleep aid in humans. While PMID 28337245 is a general review of glycine's benefits and PMID 35975308…
“The dose that I take and that was used in that study is 3 grams about 30 minutes before bed. Glycine is cheap, has essentially no side effects at this dose, and it tastes slightly sweet, which makes it easy to dissolve in water and drink.”
Huberman recommends 3 grams of glycine taken about 30 minutes before bed for sleep, noting it is cheap, has essentially no side effects at this dose, and can be dissolved in water due to its slightly sweet taste.
None of the 10 studies listed directly investigate glycine supplementation (3g) for sleep improvement. The closest relevant papers are a review on glycine's anti-inflammatory and multifarious benefits…
“The dose that I take and that was used in that study is 3 grams about 30 minutes before bed. Glycine is cheap, has essentially no side effects at this dose, and it tastes slightly sweet, which makes it easy to dissolve in water and drink.”
Huberman recommends 3 grams of glycine taken about 30 minutes before bed for sleep, noting it is cheap, has essentially no side effects at this dose, and can be dissolved in water due to its slightly sweet taste.
The provided research corpus does not contain studies directly examining glycine supplementation for sleep outcomes. The most relevant paper is the systematic review (PMID: 37851316) on glycine admini…
“Glycine is generally recognized as safe by the FDA, and the therapeutic range in studies is typically 3 to 15 grams. At 3 grams for sleep, you're well within the safe range.”
Glycine is generally recognized as safe by the FDA, and the therapeutic range in studies is typically 3 to 15 grams, with 3 grams for sleep being well within the safe range.
The provided research corpus does not contain studies that directly assess glycine's FDA GRAS status, its therapeutic dosage range, or its specific effects on sleep at 3 grams. While PMID 37851316 is…
“The key study I want to point to is by Bannai and Kawai, published in 2012 in the journal Sleep and Biological Rhythms. They gave subjects 3 grams of glycine before bed and saw significant improvements in sleep quality ratings, reductions in fatigue and sleepiness the following day, and objective improvements in polysomnography — specifically increased slow-wave sleep, which is deep non-REM sleep.”
A 2012 study by Bannai and Kawai in Sleep and Biological Rhythms found that 3 grams of glycine before bed significantly improved sleep quality ratings, reduced next-day fatigue and sleepiness, and objectively improved polysomnography results, specifically increasing slow-wave sleep.
None of the 10 retrieved studies correspond to the Bannai and Kawai (2012) Sleep and Biological Rhythms study cited by Huberman, nor do any of them investigate glycine supplementation for sleep qualit…
“The key study I want to point to is by Bannai and Kawai, published in 2012 in the journal Sleep and Biological Rhythms. They gave subjects 3 grams of glycine before bed and saw significant improvements in sleep quality ratings, reductions in fatigue and sleepiness the following day, and objective improvements in polysomnography — specifically increased slow-wave sleep, which is deep non-REM sleep.”
A 2012 study by Bannai and Kawai in Sleep and Biological Rhythms found that 3 grams of glycine before bed significantly improved sleep quality ratings, reduced next-day fatigue and sleepiness, and objectively improved polysomnography results, specifically increasing slow-wave sleep.
The expert specifically references a 2012 study by Bannai and Kawai published in Sleep and Biological Rhythms examining 3g glycine before bed and polysomnography outcomes. None of the 10 retrieved Pub…
“Glycine is generally recognized as safe by the FDA, and the therapeutic range in studies is typically 3 to 15 grams. At 3 grams for sleep, you're well within the safe range.”
Glycine is generally recognized as safe by the FDA, and the therapeutic range in studies is typically 3 to 15 grams, with 3 grams for sleep being well within the safe range.
None of the 10 provided studies directly address glycine's FDA GRAS status, its therapeutic dosing range (3–15g), or its specific use at 3g for sleep improvement. While PMID 28337245 (a narrative revi…
“The key study I want to point to is by Bannai and Kawai, published in 2012 in the journal Sleep and Biological Rhythms. They gave subjects 3 grams of glycine before bed and saw significant improvements in sleep quality ratings, reductions in fatigue and sleepiness the following day, and objective improvements in polysomnography — specifically increased slow-wave sleep, which is deep non-REM sleep.”
A 2012 study by Bannai and Kawai in Sleep and Biological Rhythms found that 3 grams of glycine before bed significantly improved sleep quality ratings, reduced next-day fatigue and sleepiness, and objectively improved polysomnography results, specifically increasing slow-wave sleep.
None of the 10 retrieved studies directly address the Bannai and Kawai (2012) study cited by Huberman, nor do they provide evidence specifically examining glycine's effects on sleep quality, polysomno…
“The key study I want to point to is by Bannai and Kawai, published in 2012 in the journal Sleep and Biological Rhythms. They gave subjects 3 grams of glycine before bed and saw significant improvements in sleep quality ratings, reductions in fatigue and sleepiness the following day, and objective improvements in polysomnography — specifically increased slow-wave sleep, which is deep non-REM sleep.”
A 2012 study by Bannai and Kawai in Sleep and Biological Rhythms found that 3 grams of glycine before bed significantly improved sleep quality ratings, reduced next-day fatigue and sleepiness, and objectively improved polysomnography results, specifically increasing slow-wave sleep.
None of the 10 retrieved studies directly address the Bannai and Kawai (2012) study cited by Huberman, nor do any of them examine glycine supplementation and sleep outcomes such as slow-wave sleep, fa…
“Glycine is generally recognized as safe by the FDA, and the therapeutic range in studies is typically 3 to 15 grams. At 3 grams for sleep, you're well within the safe range.”
Glycine is generally recognized as safe by the FDA, and the therapeutic range in studies is typically 3 to 15 grams, with 3 grams for sleep being well within the safe range.
The provided research list does not contain studies that directly address glycine's FDA GRAS status, its dosage range for sleep (3g) or therapeutic applications (3–15g), or its safety profile in human…
“Glycine is generally recognized as safe by the FDA, and the therapeutic range in studies is typically 3 to 15 grams. At 3 grams for sleep, you're well within the safe range.”
Glycine is generally recognized as safe by the FDA, and the therapeutic range in studies is typically 3 to 15 grams, with 3 grams for sleep being well within the safe range.
The provided literature includes reviews and an RCT referencing glycine supplementation (PMIDs 37510995, 28337245, 35975308), which supports glycine's general safety profile and use in therapeutic con…
“The key study I want to point to is by Bannai and Kawai, published in 2012 in the journal Sleep and Biological Rhythms. They gave subjects 3 grams of glycine before bed and saw significant improvements in sleep quality ratings, reductions in fatigue and sleepiness the following day, and objective improvements in polysomnography — specifically increased slow-wave sleep, which is deep non-REM sleep.”
A 2012 study by Bannai and Kawai in Sleep and Biological Rhythms found that 3 grams of glycine before bed significantly improved sleep quality ratings, reduced next-day fatigue and sleepiness, and objectively improved polysomnography results, specifically increasing slow-wave sleep.
None of the 10 provided studies directly address the Bannai and Kawai (2012) study cited by Huberman, nor do any of them evaluate glycine supplementation and sleep outcomes. The systematic review on g…
“Glycine is generally recognized as safe by the FDA, and the therapeutic range in studies is typically 3 to 15 grams. At 3 grams for sleep, you're well within the safe range.”
Glycine is generally recognized as safe by the FDA, and the therapeutic range in studies is typically 3 to 15 grams, with 3 grams for sleep being well within the safe range.
The provided research corpus does not contain studies directly evaluating glycine's FDA GRAS status, its dosing range, or its specific effects on sleep at 3 grams. While PMID 37851316 (a systematic re…
“Glycine is generally recognized as safe by the FDA, and the therapeutic range in studies is typically 3 to 15 grams. At 3 grams for sleep, you're well within the safe range.”
Glycine is generally recognized as safe by the FDA, and the therapeutic range in studies is typically 3 to 15 grams, with 3 grams for sleep being well within the safe range.
The glycine safety claim and dosage range are partially supported by the available literature. The GlyNAC RCT (PMID: 35975308) and multiple reviews on glycine (PMIDs: 37510995, 28337245) confirm glyci…
“The key study I want to point to is by Bannai and Kawai, published in 2012 in the journal Sleep and Biological Rhythms. They gave subjects 3 grams of glycine before bed and saw significant improvements in sleep quality ratings, reductions in fatigue and sleepiness the following day, and objective improvements in polysomnography — specifically increased slow-wave sleep, which is deep non-REM sleep.”
A 2012 study by Bannai and Kawai in Sleep and Biological Rhythms found that 3 grams of glycine before bed significantly improved sleep quality ratings, reduced next-day fatigue and sleepiness, and objectively improved polysomnography results, specifically increasing slow-wave sleep.
The expert's claim specifically references a 2012 study by Bannai and Kawai published in Sleep and Biological Rhythms, but this study does not appear in any of the 10 provided PubMed references. While…
“Glycine is generally recognized as safe by the FDA, and the therapeutic range in studies is typically 3 to 15 grams. At 3 grams for sleep, you're well within the safe range.”
Glycine is generally recognized as safe by the FDA, and the therapeutic range in studies is typically 3 to 15 grams, with 3 grams for sleep being well within the safe range.
None of the 10 provided studies directly examine glycine's FDA GRAS status, its therapeutic dosing range, or its specific effects on sleep at 3 grams. While PMID 28337245 (a narrative review on glycin…
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Claims are extracted from publicly available podcasts and videos, attributed to their source, and compared against PubMed research. This is educational information only — consult a healthcare provider before starting any supplement.
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