Does Andrew Huberman recommend Lion's Mane Mushroom?
Andrew Huberman recommends Lion's Mane Mushroom in some contexts, but has also raised cautions.
Published research rates it weak evidence. Of Andrew Huberman's 63 tracked claims, 14 are supported or partially supported by studies on PubMed.
Evidence last reviewed May 2026
Andrew Huberman on Lion's Mane Mushroom — 63 claims
“The bioactive compounds are concentrated in the fruiting body, not the mycelium. Many cheaper supplements are mycelium grown on grain, which has much lower concentrations of active compounds.”
The bioactive compounds in lion's mane are concentrated in the fruiting body, not the mycelium, and many cheaper supplements use mycelium grown on grain, which has much lower concentrations of active compounds.
None of the 10 studies listed directly compare bioactive compound concentrations between lion's mane fruiting body and mycelium-on-grain preparations, nor do they assess clinical outcome differences b…
“Typical doses in trials range from 500 milligrams to 3 grams per day.”
Typical doses of lion's mane used in trials range from 500 milligrams to 3 grams per day.
The published RCTs listed are consistent with Huberman's stated dosage range of 500 mg to 3 g per day. PMID 38004235 used 1.8 g/day in young adults, PMID 18844328 used doses in the range consistent wi…
“The bioactive compounds are concentrated in the fruiting body, not the mycelium. Many cheaper supplements are mycelium grown on grain, which has much lower concentrations of active compounds.”
The bioactive compounds in lion's mane are concentrated in the fruiting body, not the mycelium; many cheaper supplements use mycelium grown on grain, which has much lower concentrations of active compounds.
None of the 10 studies in the provided list directly compare fruiting body versus mycelium preparations in terms of bioactive compound concentrations or clinical efficacy. The RCT by Mori et al. (PMID…
“Look for dual-extract products using the fruiting body.”
For lion's mane supplementation, one should look for dual-extract products using the fruiting body.
No relevant PubMed studies were retrieved to assess this claim.
“Look for dual-extract products using the fruiting body.”
For lion's mane supplementation, one should look for dual-extract products using the fruiting body.
No relevant PubMed studies were retrieved to assess this claim.
“Look for dual-extract products using the fruiting body.”
For lion's mane supplementation, one should look for dual-extract products using the fruiting body.
None of the 10 studies provided directly evaluate or compare dual-extract products versus single-extract, or fruiting body versus mycelium formulations in terms of cognitive or mood outcomes in humans…
“Look for dual-extract products using the fruiting body.”
For lion's mane supplementation, one should look for dual-extract products using the fruiting body.
No relevant PubMed studies were retrieved to assess this claim.
“Look for dual-extract products using the fruiting body.”
For lion's mane supplementation, one should look for dual-extract products using the fruiting body.
No relevant PubMed studies were retrieved to assess this claim.
“A follow-up study with healthy adults showed improvements in short-term memory and attention.”
A follow-up study in healthy adults showed improvements in short-term memory and attention with lion's mane.
No relevant PubMed studies were retrieved to assess this claim.
“In mice, lion's mane has improved memory, reduced anxiety-like behavior, stimulated hippocampal neurogenesis, and even shown neuroprotective effects in models of Alzheimer's disease.”
In animal models, lion's mane has improved memory, reduced anxiety-like behavior, stimulated hippocampal neurogenesis, and shown neuroprotective effects in models of Alzheimer's disease.
Huberman's claim specifically concerns animal model evidence for lion's mane improving memory, reducing anxiety, stimulating hippocampal neurogenesis, and showing neuroprotective effects in Alzheimer'…
“A follow-up study with healthy adults showed improvements in short-term memory and attention.”
A follow-up study with healthy adults showed improvements in short-term memory and attention from lion's mane supplementation.
The RCT by PMID 38004235 (double-blind, parallel-groups pilot study, 28-day intervention, 1.8g dose) investigated cognitive and mood effects in young adults and found improvements following lion's man…
“In mice, lion's mane has improved memory, reduced anxiety-like behavior, stimulated hippocampal neurogenesis, and even shown neuroprotective effects in models of Alzheimer's disease.”
In animal studies, lion's mane has improved memory, reduced anxiety-like behavior, stimulated hippocampal neurogenesis, and shown neuroprotective effects in models of Alzheimer's disease.
The expert's claim specifically concerns animal studies showing memory improvement, anxiety reduction, hippocampal neurogenesis, and neuroprotective effects in Alzheimer's models. The provided literat…
“Typical doses in trials range from 500 milligrams to 3 grams per day.”
Typical doses of lion's mane used in trials range from 500 milligrams to 3 grams per day.
The available studies directly corroborate Huberman's claim about the dosage range. The RCT by PMID 38004235 used 1.8 g/day, PMID 31413233 used an oral supplement over 12 weeks, and PMID 18844328 stud…
“In mice, lion's mane has improved memory, reduced anxiety-like behavior, stimulated hippocampal neurogenesis, and even shown neuroprotective effects in models of Alzheimer's disease.”
In animal studies, lion's mane has improved memory, reduced anxiety-like behavior, stimulated hippocampal neurogenesis, and shown neuroprotective effects in models of Alzheimer's disease in mice.
No relevant PubMed studies were retrieved to assess this claim.
“In mice, lion's mane has improved memory, reduced anxiety-like behavior, stimulated hippocampal neurogenesis, and even shown neuroprotective effects in models of Alzheimer's disease.”
In animal studies, lion's mane has improved memory, reduced anxiety-like behavior, stimulated hippocampal neurogenesis, and shown neuroprotective effects in models of Alzheimer's disease in mice.
Huberman's claim specifically references animal (mouse) studies showing memory improvement, anxiety reduction, hippocampal neurogenesis, and Alzheimer's model neuroprotection. None of the 10 provided…
“There's a notable Japanese trial from 2009 with 30 patients with mild cognitive impairment who showed significant improvement in cognitive scores after 16 weeks of lion's mane supplementation, with decline after stopping.”
A 2009 Japanese trial with 30 patients with mild cognitive impairment showed significant improvement in cognitive scores after 16 weeks of lion's mane supplementation, with decline after stopping.
PMID 18844328 directly corresponds to the trial Huberman describes: a double-blind, placebo-controlled study in 50-80 year old Japanese individuals with mild cognitive impairment using Hericium erinac…
“A follow-up study with healthy adults showed improvements in short-term memory and attention.”
A follow-up study in healthy adults showed improvements in short-term memory and attention with lion's mane.
The RCT by Jurgens et al. (PMID: 38004235) directly examined cognitive effects including attention in healthy young adults over 28 days, finding some acute cognitive benefits following a single dose o…
“There's also a small trial showing reduced depression and anxiety in overweight or obese adults.”
A small trial showed reduced depression and anxiety in overweight or obese adults taking lion's mane.
None of the 10 studies provided specifically examine depression and anxiety outcomes in overweight or obese adults taking lion's mane. The available RCTs (PMIDs 38004235, 31413233, 18844328, 38140277)…
“In mice, lion's mane has improved memory, reduced anxiety-like behavior, stimulated hippocampal neurogenesis, and even shown neuroprotective effects in models of Alzheimer's disease.”
In animal studies, lion's mane has improved memory, reduced anxiety-like behavior, stimulated hippocampal neurogenesis, and shown neuroprotective effects in models of Alzheimer's disease in mice.
No relevant PubMed studies were retrieved to assess this claim.
“There's also a small trial showing reduced depression and anxiety in overweight or obese adults.”
A small trial showed that lion's mane reduced depression and anxiety in overweight or obese adults.
None of the 10 listed studies specifically examined lion's mane supplementation in overweight or obese adults measuring depression and anxiety outcomes. The closest human RCTs (PMIDs 38004235, 3141323…
Other supplements Andrew Huberman discusses
Claims are extracted from publicly available podcasts and videos, attributed to their source, and compared against PubMed research. This is educational information only — consult a healthcare provider before starting any supplement.
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