Does Andrew Huberman recommend NMN (Nicotinamide Mononucleotide)?
Andrew Huberman recommends NMN (Nicotinamide Mononucleotide) in some contexts, but has also raised cautions.
Published research rates it weak evidence. Of Andrew Huberman's 81 tracked claims, 65 are supported or partially supported by studies on PubMed.
Evidence last reviewed May 2026
Andrew Huberman on NMN (Nicotinamide Mononucleotide) β 81 claims
βThere's a study showing improved muscle insulin sensitivity in overweight postmenopausal womenβ
A study showed NMN improved muscle insulin sensitivity in overweight postmenopausal women.
PMID 33888596 is an RCT directly titled 'Nicotinamide mononucleotide increases muscle insulin sensitivity in prediabetic women,' which closely aligns with Huberman's claim. However, the expert describβ¦
βStudies have used anywhere from 250 milligrams to 1200 milligrams per day.β
Studies have used NMN doses ranging from 250 milligrams to 1200 milligrams per day, and dosing remains an open question.
The available studies include multiple RCTs and reviews examining NMN supplementation, and the published literature does reflect a range of doses across human trials consistent with Huberman's claim.β¦
βa study in recreational runners showing improved aerobic capacityβ
A study in recreational runners showed NMN improved aerobic capacity.
A directly relevant RCT (PMID: 34238308) titled 'Nicotinamide mononucleotide supplementation enhances aerobic capacity in amateur runners: a randomized, double-blind study' appears to directly supportβ¦
βNMN supplementation in aged mice has reversed muscle wasting, improved energy metabolism, and even extended lifespan in some studies.β
In aged mice, NMN supplementation has reversed muscle wasting, improved energy metabolism, and extended lifespan in some studies.
Huberman's claim specifically concerns aged mice showing muscle wasting reversal, improved energy metabolism, and lifespan extension with NMN supplementation. None of the 10 provided studies are animaβ¦
βThere are now a handful of human clinical trials showing that oral NMN supplementation does raise blood NAD+ levels β that part seems to work.β
Human clinical trials have shown that oral NMN supplementation does raise blood NAD+ levels.
Multiple RCTs in the provided evidence list appear directly relevant to the claim. PMID 38789831 is explicitly titled as showing that NMN 'increased blood NAD levels' in older adults in a double-blindβ¦
βThere are now a handful of human clinical trials showing that oral NMN supplementation does raise blood NAD+ levels β that part seems to work.β
Human clinical trials have shown that oral NMN supplementation raises blood NAD+ levels.
Multiple RCTs in the provided literature directly support the claim that oral NMN supplementation raises blood NAD+ levels in humans. PMID 38789831 (n=60 older adults, 12 weeks, double-blind placebo-cβ¦
βNMN supplementation in aged mice has reversed muscle wasting, improved energy metabolism, and even extended lifespan in some studies.β
In aged mice, NMN supplementation has reversed muscle wasting, improved energy metabolism, and extended lifespan in some studies.
The expert's claim specifically concerns aged mice β covering muscle wasting reversal, improved energy metabolism, and lifespan extension β but none of the 10 provided studies are animal studies; allβ¦
βThere's a study showing improved muscle insulin sensitivity in overweight postmenopausal womenβ
A study showed NMN improved muscle insulin sensitivity in overweight postmenopausal women.
PMID 33888596 is an RCT directly studying NMN and muscle insulin sensitivity, and its title references 'prediabetic women,' which partially aligns with Huberman's claim about 'overweight postmenopausaβ¦
βa study in recreational runners showing improved aerobic capacityβ
A study in recreational runners showed NMN improved aerobic capacity.
None of the 10 published studies provided in the evidence base specifically examined NMN's effects on aerobic capacity in recreational runners. The closest relevant RCTs focus on insulin sensitivity (β¦
βThere are now a handful of human clinical trials showing that oral NMN supplementation does raise blood NAD+ levels β that part seems to work.β
Human clinical trials have shown that oral NMN supplementation does raise blood NAD+ levels.
Multiple RCTs in the provided literature directly address oral NMN supplementation in humans, including PMID 38789831 which explicitly reports increased blood NAD levels in older adults following NMNβ¦
βNMN supplementation in aged mice has reversed muscle wasting, improved energy metabolism, and even extended lifespan in some studies.β
In aged mice, NMN supplementation has reversed muscle wasting, improved energy metabolism, and extended lifespan in some studies.
Huberman's claim specifically concerns aged mice β referencing reversal of muscle wasting, improved energy metabolism, and lifespan extension in animal models. None of the 10 provided studies are animβ¦
βThere's a study showing improved muscle insulin sensitivity in overweight postmenopausal womenβ
A study showed NMN improved muscle insulin sensitivity in overweight postmenopausal women.
PMID 33888596 is an RCT whose title directly references NMN increasing muscle insulin sensitivity in prediabetic women, which aligns closely with Huberman's claim. However, the expert described the poβ¦
βStudies have used anywhere from 250 milligrams to 1200 milligrams per day.β
Studies have used NMN doses ranging from 250 milligrams to 1200 milligrams per day, and dosing remains an open question.
The published research corpus includes multiple RCTs and reviews examining NMN supplementation in humans, and the studies listed span a range of doses consistent with Huberman's claim (e.g., the dose-β¦
βa study in recreational runners showing improved aerobic capacityβ
A study in recreational runners showed NMN improved aerobic capacity.
None of the 10 studies in the provided research list specifically examined NMN's effects on aerobic capacity in recreational runners. The available RCTs focused on outcomes such as insulin sensitivityβ¦
βStudies have used anywhere from 250 milligrams to 1200 milligrams per day.β
Studies have used NMN doses ranging from 250 milligrams to 1200 milligrams per day, and dosing remains an open question.
The published research listed includes multiple RCTs and reviews examining NMN supplementation in humans, and the dose range of 250β1200 mg/day cited by Huberman is broadly consistent with doses usedβ¦
βThere are now a handful of human clinical trials showing that oral NMN supplementation does raise blood NAD+ levels β that part seems to work.β
Human clinical trials have shown that oral NMN supplementation does raise blood NAD+ levels.
Multiple RCTs in the provided literature (PMIDs 38789831, 36797393, 36002548, 36482258) appear to investigate NMN supplementation in human adults, and at least one RCT (PMID 38789831) explicitly referβ¦
βNMN supplementation in aged mice has reversed muscle wasting, improved energy metabolism, and even extended lifespan in some studies.β
In aged mice, NMN supplementation has reversed muscle wasting, improved energy metabolism, and extended lifespan in some studies.
The expert's claim specifically concerns aged mice β covering muscle wasting reversal, improved energy metabolism, and lifespan extension β but none of the 10 provided studies are animal studies; allβ¦
βa study in recreational runners showing improved aerobic capacityβ
A study in recreational runners showed NMN improved aerobic capacity.
None of the 10 studies in the provided research list specifically investigated NMN's effects on aerobic capacity in recreational runners. The available RCTs examined outcomes such as insulin sensitiviβ¦
βsome data on cardiovascular function. But we don't yet have large long-term trials on hard outcomes like disease prevention or longevity in humans.β
There is some human data on NMN and cardiovascular function, but no large long-term trials on hard outcomes like disease prevention or longevity.
The expert's claim is well-supported by the available literature. Human data on NMN and cardiovascular function does exist β PMID 36797393 is an RCT specifically examining NMN supplementation and arteβ¦
βThere are now a handful of human clinical trials showing that oral NMN supplementation does raise blood NAD+ levels β that part seems to work.β
Human clinical trials have shown that oral NMN supplementation does raise blood NAD+ levels.
Multiple RCTs in the provided list (PMIDs 36797393, 38789831, 36002548, 36482258) appear to examine NMN supplementation in human populations, and at least one RCT (PMID 38789831) explicitly reports inβ¦
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Claims are extracted from publicly available podcasts and videos, attributed to their source, and compared against PubMed research. This is educational information only β consult a healthcare provider before starting any supplement.
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