Does David Sinclair recommend Vitamin B Complex?
Yes — David Sinclair has directly recommended Vitamin B Complex.
Published research rates it moderate evidence. Of David Sinclair's 11 tracked claims, 0 are supported or partially supported by studies on PubMed.
Evidence last reviewed May 2026
David Sinclair on Vitamin B Complex — 11 claims
“And the best way to do that is to make sure B12 levels are optimal.”
The best way to keep homocysteine levels down is to ensure B12 levels are optimal.
“one of the first things to worry about if you if you're just focusing on plants only is a deficiency uh in vitamin B12.”
One of the first nutritional concerns for those on a plant-based diet is deficiency in vitamin B12.
“B vitamins, especially if you're on a plant-based diet, but for everybody, don't be deficient in these.”
B vitamins (especially B12, B6, and B3) are important for everyone, but particularly for those on a plant-based diet, who risk deficiency.
“there are a lot of studies that have shown that deficiencies in B12 accelerate a variety of diseases. Heart disease in is the major one, but also dementia in the in the brain.”
Studies have shown that deficiencies in B12 accelerate heart disease and dementia.
“studies that have shown accelerate a variety of diseases, heart disease is the major one, but also dementia in the brain. think what's going on is that aging is being accelerated of these B vitamins.”
Low levels of B vitamins are associated with accelerated aging and a variety of diseases, including heart disease and dementia.
“Because the B vitamins are the ones that make sure you have the the methyls that are added and subtracted from the DNA that controls the DNA methylation clock.”
B vitamins control DNA methylation by providing the methyl groups added and subtracted from DNA, which regulates the DNA methylation clock.
“the B vitamins are one are the ones that make sure you have the the methyls that are added and subtracted from the DNA that controls the DNA methylation clock”
B vitamins ensure you have the methyl groups needed for DNA methylation, which controls the DNA methylation clock.
“And the result of low B vitamins is an elevated level of homocysteines. - Well, that's a markers, yeah, exactly. measures homocysteine levels because it's been shown to go up disease and dementia.”
Low B vitamin levels result in elevated homocysteine levels, which are a marker associated with heart disease and dementia.
“the main reason I think what's going on is that aging is being accelerated when you don't have enough of these B vitamins.”
Sinclair believes that aging is accelerated when you don't have enough B vitamins.
“If you have low levels of B12, it's known that you have deficiency in the ability to methylate DNA, and that will mess up your epigenome and very likely accelerate the clock in a way that causes aging.”
Low levels of B12 are known to cause deficiency in the ability to methylate DNA, which disrupts the epigenome and very likely accelerates the aging clock.
“measure my B vitamins.”
Sinclair personally measures his B vitamin levels.
Other supplements David Sinclair discusses
Claims are extracted from publicly available podcasts and videos, attributed to their source, and compared against PubMed research. This is educational information only — consult a healthcare provider before starting any supplement.
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