Does David Sinclair recommend NMN (Nicotinamide Mononucleotide)?
Yes — David Sinclair has directly recommended NMN (Nicotinamide Mononucleotide).
Published research rates it weak evidence. Of David Sinclair's 9 tracked claims, 0 are supported or partially supported by studies on PubMed.
Evidence last reviewed May 2026
David Sinclair on NMN (Nicotinamide Mononucleotide) — 9 claims
“under the age of 25, you thought that um supplementation and things like that perhaps were not quite so necessary, at least with regards to I think specifically NMN or NAD boosters and stuff like that.”
For people under approximately 25 years old, NMN or NAD booster supplementation may not be as necessary.
“we've tested these side by side which is what a good scientist should do and so far nmn is the winner”
Sinclair has tested NMN and NADH side by side and found NMN to be superior so far.
“without nad we're all dead in 30 seconds it's really important it's the molecule of life it is over time the levels decline if you measure the skin nad levels in a 50 year old like me i'm 52 they would be half the levels of when i was 20 which is not good for metabolism and enzymatic reactions in the body but it's also bad because nad is required for the body to defend itself against aging”
Without NAD, we would die within 30 seconds — it is the molecule of life and is essential for metabolism, enzymatic reactions, and the body's defense against aging.
“the full name if you want to hear it is nicotinamide mononucleotide but it's just a small chemical that the body takes in as a vitamin and turns it into a really important chemical in the body called nad”
NMN (nicotinamide mononucleotide) is a small chemical that the body takes in as a vitamin and turns into NAD, an important chemical in the body.
“yes so nadh and nad are larger molecules uh and nmn is a precursor building block and it's small enough that uh it does get taken up into cells and so that's why i take nmn”
NMN is a precursor to NAD. It is a smaller molecule than NAD or NADH and is small enough to be taken up into cells, which is why Sinclair prefers it.
“if you measure the skin nad levels in a 50 year old like me i'm 52 they would be half the levels of when i was 20 which is not good for metabolism and enzymatic reactions in the body but it's also bad because nad is required for the body to defend itself against aging”
NAD levels in a 50-year-old are approximately half what they were at age 20, which negatively affects metabolism, enzymatic reactions, and the body's ability to defend against aging.
“Supplementation, still NMN, resveratrol, some metformin, uh vitamin D... it hasn't changed since I wrote uh Lifespan 18 months ago.”
David Sinclair personally takes NMN as part of his daily supplementation routine, which has remained unchanged since writing his book Lifespan.
“you take metformin daily and you also take nmn”
Sinclair takes NMN personally.
“NMN is nicotinamide mononucleotide, but on online it's called NMN. Don't confuse that with M&Ms. You will not live longer.”
NMN stands for nicotinamide mononucleotide and is referred to online as NMN.
Other supplements David Sinclair discusses
Claims are extracted from publicly available podcasts and videos, attributed to their source, and compared against PubMed research. This is educational information only — consult a healthcare provider before starting any supplement.
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