Does David Sinclair recommend Vitamin B12?
Yes — David Sinclair has directly recommended Vitamin B12.
Published research rates it strong evidence. Of David Sinclair's 6 tracked claims, 5 are supported or partially supported by studies on PubMed.
Evidence last reviewed May 2026
David Sinclair on Vitamin B12 — 6 claims
“one of the first things to worry about if you're just focusing on plants only is a deficiency in vitamin B12... if you're a vegan or a vegetarian, you're going to be lacking in vitamin B12 probably.”
People on plant-based diets are likely to be deficient in vitamin B12.
Multiple studies in the provided literature directly support the claim that individuals on plant-based or vegan diets are at elevated risk for vitamin B12 deficiency. The review on 'Vitamin B12 among…
“B vitamins, especially if you're on a plant-based diet, but for everybody, don't be deficient in these.”
B vitamins, especially B12, should not be deficient in anyone — not just those on plant-based diets.
The research broadly supports the importance of avoiding B12 deficiency across the general population, not solely in plant-based dieters. PMID 40961307 notes that B12 deficiency affects approximately…
“the best way to do that is to make sure B12 levels are optimal... homocysteine levels... it's been shown to go up [with] disease and dementia.”
Ensuring optimal B12 levels is the best way to keep homocysteine levels down, as elevated homocysteine is associated with heart disease and dementia.
The association between elevated homocysteine and heart disease/dementia risk has broader scientific support, and B12's role in homocysteine metabolism is well-established biochemically—reflected in r…
“there are a lot of studies that have shown that deficiencies in B12 accelerate a variety of diseases. Heart disease is the major one, but also dementia in the brain.”
Deficiencies in B12 have been shown in studies to accelerate a variety of diseases, particularly heart disease and dementia.
The provided literature supports a link between B12 deficiency and neurological/cognitive harm, with the systematic review on vitamin supplementation and dementia (PMID 35268010) and the B12 deficienc…
“If you have low levels of B12, it's known that you have deficiency in the ability to methylate DNA, and that will mess up your epigenome, and very likely accelerate the clock in a way that causes aging.”
Low levels of B12 cause a deficiency in the ability to methylate DNA, which messes up the epigenome and likely accelerates the aging clock.
The mechanistic link between B12 and methylation is supported by several reviews in the evidence base. PMID 27916823 confirms B12 acts as a cofactor in one-carbon transfers through methylation and mol…
“measure my B vitamins.”
Sinclair measures his own B vitamin levels to monitor his health.
The published research provided focuses on clinical outcomes of vitamin B12 supplementation, deficiency prevalence, and therapeutic use in specific populations — none of it addresses personal health m…
Other supplements David Sinclair discusses
Claims are extracted from publicly available podcasts and videos, attributed to their source, and compared against PubMed research. This is educational information only — consult a healthcare provider before starting any supplement.
Back to David Sinclair