Does David Sinclair recommend Vitamin B12?
Yes — David Sinclair has directly recommended Vitamin B12.
Published research rates it strong evidence. Of David Sinclair's 6 tracked claims, 0 are supported or partially supported by studies on PubMed.
Evidence last reviewed May 2026
David Sinclair on Vitamin B12 — 6 claims
“B vitamins, especially if you're on a plant-based diet, but for everybody, don't be deficient in these.”
B vitamins, especially B12, should not be deficient in anyone — not just those on plant-based diets.
“the best way to do that is to make sure B12 levels are optimal... homocysteine levels... it's been shown to go up [with] disease and dementia.”
Ensuring optimal B12 levels is the best way to keep homocysteine levels down, as elevated homocysteine is associated with heart disease and dementia.
“one of the first things to worry about if you're just focusing on plants only is a deficiency in vitamin B12... if you're a vegan or a vegetarian, you're going to be lacking in vitamin B12 probably.”
People on plant-based diets are likely to be deficient in vitamin B12.
“there are a lot of studies that have shown that deficiencies in B12 accelerate a variety of diseases. Heart disease is the major one, but also dementia in the brain.”
Deficiencies in B12 have been shown in studies to accelerate a variety of diseases, particularly heart disease and dementia.
“If you have low levels of B12, it's known that you have deficiency in the ability to methylate DNA, and that will mess up your epigenome, and very likely accelerate the clock in a way that causes aging.”
Low levels of B12 cause a deficiency in the ability to methylate DNA, which messes up the epigenome and likely accelerates the aging clock.
“measure my B vitamins.”
Sinclair measures his own B vitamin levels to monitor his health.
Other supplements David Sinclair discusses
Claims are extracted from publicly available podcasts and videos, attributed to their source, and compared against PubMed research. This is educational information only — consult a healthcare provider before starting any supplement.
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