Resveratrol
PolyphenolAlso known as: Trans-resveratrol · 3,5,4'-trihydroxystilbene
A polyphenol found in red grape skins that activates SIRT1 (sirtuins). Extensively studied for longevity, cardiovascular health, and insulin sensitivity. Bioavailability is low and human clinical evidence is mixed.
Evidence comparisons not yet run for these claims.
Expert Mentions
All 13 mentions"This 'antioxidant paradox' is something I take seriously."
Patrick takes seriously the 'antioxidant paradox' — the concern that resveratrol's antioxidant activity may suppress beneficial ROS signaling from exercise.
"it's been at the center of longevity research since David Sinclair's landmark 2003 paper showing it activated sirtuins and extended lifespan in yeast"
Resveratrol has been at the center of longevity research since David Sinclair's 2003 paper showing it activated sirtuins and extended lifespan in yeast.