Abstraction Health

Urolithin A — Expert Claims

Extracted from publicly available podcast transcripts and videos. Each claim is attributed and sourced.

Expert Consensus

Pending review
1/5
Experts mention
1
Recommend
1
Flag caution
MH
Mark Hyman Recommends Caution
Pending review26 claims1000mg

Claims are extracted using AI (Claude) from publicly available transcripts and manually reviewed. Extraction confidence (high / medium / low) indicates accuracy of capture. Each claim is compared against PubMed research.

Experts in this data:Mark Hyman

26 expert mentions

MH
Mark Hyman
Cleveland Clinic Center for Functional Medicine
Direct recommendation

one of the most promising compounds to do this is something called urolithin A

Extracted claim

Urolithin A is one of the most promising compounds for targeting mitochondrial decline for healthy aging.

Not yet assessedHigh confidence
MH
Mark Hyman
Cleveland Clinic Center for Functional Medicine
Direct recommendation

one of the most promising compounds to do this is something called urolithin A

Extracted claim

Urolithin A is one of the most promising compounds for targeting mitochondrial decline for healthy aging.

Not yet assessedHigh confidence
MH
Mark Hyman
Cleveland Clinic Center for Functional Medicine
Evidence-backed claim

A new clinical trial in healthy, middle-aged adults found that just 4 weeks of supplementing with 1,000 mg of urolithin A, which is what I take every day, led to a more youthful immune profile. T cells became more responsive, the immune system got better at clearing threats, markers of inflammation, they all went down, all while mitochondrial energy production improved across the board.

Extracted claim

A new clinical trial found that 4 weeks of supplementing with 1,000 mg of urolithin A daily led to a more youthful immune profile in healthy middle-aged adults, with T cells becoming more responsive, the immune system getting better at clearing threats, markers of inflammation going down, and mitochondrial energy production improving.

1000 mgdaily📍 4 weeks of daily supplementation in healthy middle-aged adults
Not yet assessedHigh confidence
MH
Mark Hyman
Cleveland Clinic Center for Functional Medicine
Evidence-backed claim

A new clinical trial in healthy, middle-aged adults found that just 4 weeks of supplementing with 1,000 mg of urolithin A, which is what I take every day, led to a more youthful immune profile. T cells became more responsive, the immune system got better at clearing threats, markers of inflammation, they all went down, all while mitochondrial energy production improved across the board.

Extracted claim

A new clinical trial found that 4 weeks of supplementing with 1,000 mg of urolithin A daily led to a more youthful immune profile in healthy middle-aged adults, with T cells becoming more responsive, the immune system getting better at clearing threats, markers of inflammation going down, and mitochondrial energy production improving.

1000 mgdaily📍 4 weeks of daily supplementation in healthy middle-aged adults
Not yet assessedHigh confidence
MH
Mark Hyman
Cleveland Clinic Center for Functional Medicine
Evidence-backed claim

science has already shown that urolithin A supports muscle and skin health

Extracted claim

Urolithin A supports muscle and skin health, as already shown by science.

Not yet assessedHigh confidence
MH
Mark Hyman
Cleveland Clinic Center for Functional Medicine
Evidence-backed claim

urolithin A that is the result of a input from a pro a food product from a from a plant from a pomegranate juice that gets transformed by a fraction of us into a product that has immense benefit. So, company was founded based on this. Amazentis actually sells this product.

Extracted claim

Urolithin A, derived from pomegranate juice via microbiome transformation, has immense benefit, and a company (Amazentis) was founded to sell it as a product.

Not yet assessedMedium confidence
MH
Mark Hyman
Cleveland Clinic Center for Functional Medicine
Evidence-backed claim

urolithin A that is the result of a input from a pro a food product from a from a plant from a pomegranate juice that gets transformed by a fraction of us into a product that has immense benefit. So, company was founded based on this. Amazentis actually sells this product.

Extracted claim

Urolithin A, derived from pomegranate juice via microbiome transformation, has immense benefit, and a company (Amazentis) was founded to sell it as a product.

Not yet assessedMedium confidence
MH
Mark Hyman
Cleveland Clinic Center for Functional Medicine
Evidence-backed claim

science has already shown that urolithin A supports muscle and skin health

Extracted claim

Urolithin A supports muscle and skin health, as already shown by science.

Not yet assessedHigh confidence
MH
Mark Hyman
Cleveland Clinic Center for Functional Medicine
Mechanism discussion

it's a natural molecule that your body can make when you have the right gut bacteria to convert compounds found in foods like pomegranate and walnuts

Extracted claim

Urolithin A is a natural molecule the body can produce when the right gut bacteria convert compounds found in foods like pomegranate and walnuts.

Not yet assessedHigh confidence
MH
Mark Hyman
Cleveland Clinic Center for Functional Medicine
Mechanism discussion

only 30 to 40% of people can produce urolithin A naturally

Extracted claim

Only 30 to 40% of people can produce urolithin A naturally.

Not yet assessedHigh confidence
MH
Mark Hyman
Cleveland Clinic Center for Functional Medicine
Mechanism discussion

these compounds are not acting by themselves. They are actually metabolized by your microbiome. And that's really And the products of that is made by by your microbiome is is called urolithin A.

Extracted claim

Ellagitannins from pomegranate are not acting by themselves; they are metabolized by the gut microbiome, and the product of that metabolism is urolithin A.

Not yet assessedHigh confidence
MH
Mark Hyman
Cleveland Clinic Center for Functional Medicine
Mechanism discussion

only 30 to 40% of people can produce urolithin A naturally

Extracted claim

Only 30 to 40% of people can produce urolithin A naturally.

Not yet assessedHigh confidence
MH
Mark Hyman
Cleveland Clinic Center for Functional Medicine
Mechanism discussion

urolithin A has this remarkable ability to activate mitophagy. Mitophagy is not sort of the as the term implies, it's eating mitochondria, but it doesn't eat them discriminately. It eats the old, defective mitochondria

Extracted claim

Urolithin A activates mitophagy, which selectively removes old and defective mitochondria.

Not yet assessedHigh confidence
MH
Mark Hyman
Cleveland Clinic Center for Functional Medicine
Mechanism discussion

it's a natural molecule that your body can make when you have the right gut bacteria to convert compounds found in foods like pomegranate and walnuts

Extracted claim

Urolithin A is a natural molecule the body can produce when the right gut bacteria convert compounds found in foods like pomegranate and walnuts.

Not yet assessedHigh confidence
MH
Mark Hyman
Cleveland Clinic Center for Functional Medicine
Mechanism discussion

we don't make, for example, one of these postbiotics called urolithin A, so we make it from pomegranate or other ellagitannins that are in, you know, walnuts or berries or whatever.

Extracted claim

Urolithin A is a postbiotic that humans do not make themselves; it is produced by gut microbiome metabolism of ellagitannins found in pomegranate, walnuts, berries, and similar foods.

Not yet assessedHigh confidence
MH
Mark Hyman
Cleveland Clinic Center for Functional Medicine
Mechanism discussion

urolithin A has this remarkable ability to activate mitophagy. Mitophagy is not sort of the as the term implies, it's eating mitochondria, but it doesn't eat them discriminately. It eats the old, defective mitochondria

Extracted claim

Urolithin A activates mitophagy, which selectively removes old and defective mitochondria.

Not yet assessedHigh confidence
MH
Mark Hyman
Cleveland Clinic Center for Functional Medicine
Mechanism discussion

only about 35% of people whose microbiome cuz remember, all of our microbiomes are different. And some 60% of people's microbiome is not able to make that conversion.

Extracted claim

Only about 35% of people have a microbiome capable of converting ellagitannins into urolithin A; approximately 60% of people's microbiomes cannot make that conversion.

Not yet assessedHigh confidence
MH
Mark Hyman
Cleveland Clinic Center for Functional Medicine
Mechanism discussion

we don't make, for example, one of these postbiotics called urolithin A, so we make it from pomegranate or other ellagitannins that are in, you know, walnuts or berries or whatever.

Extracted claim

Urolithin A is a postbiotic that humans do not make themselves; it is produced by gut microbiome metabolism of ellagitannins found in pomegranate, walnuts, berries, and similar foods.

Not yet assessedHigh confidence
MH
Mark Hyman
Cleveland Clinic Center for Functional Medicine
Mechanism discussion

these compounds are not acting by themselves. They are actually metabolized by your microbiome. And that's really And the products of that is made by by your microbiome is is called urolithin A.

Extracted claim

Ellagitannins from pomegranate are not acting by themselves; they are metabolized by the gut microbiome, and the product of that metabolism is urolithin A.

Not yet assessedHigh confidence
MH
Mark Hyman
Cleveland Clinic Center for Functional Medicine
Mechanism discussion

only about 35% of people whose microbiome cuz remember, all of our microbiomes are different. And some 60% of people's microbiome is not able to make that conversion.

Extracted claim

Only about 35% of people have a microbiome capable of converting ellagitannins into urolithin A; approximately 60% of people's microbiomes cannot make that conversion.

Not yet assessedHigh confidence
MH
Mark Hyman
Cleveland Clinic Center for Functional Medicine
Personal anecdote

which I by by the way take every day because the literature is impressive on it.

Extracted claim

Mark Hyman takes urolithin A every day because the literature on it is impressive.

every day
Not yet assessedHigh confidence
MH
Mark Hyman
Cleveland Clinic Center for Functional Medicine
Personal anecdote

1,000 mg of urolithin A, which is what I take every day... I take it every single day

Extracted claim

Mark Hyman personally takes 1,000 mg of urolithin A (as Mitopure) every single day.

1000 mgevery day📍 taken daily as Mitopure from Timeline
Not yet assessedHigh confidence
MH
Mark Hyman
Cleveland Clinic Center for Functional Medicine
Personal anecdote

1,000 mg of urolithin A, which is what I take every day... I take it every single day

Extracted claim

Mark Hyman personally takes 1,000 mg of urolithin A (as Mitopure) every single day.

1000 mgevery day📍 taken daily as Mitopure from Timeline
Not yet assessedHigh confidence
MH
Mark Hyman
Cleveland Clinic Center for Functional Medicine
Personal anecdote

which I by by the way take every day because the literature is impressive on it.

Extracted claim

Mark Hyman takes urolithin A every day because the literature on it is impressive.

every day
Not yet assessedHigh confidence
MH
Mark Hyman
Cleveland Clinic Center for Functional Medicine
Caution / warning

not all urolithin A is clinically tested and third-party certified

Extracted claim

Not all urolithin A products are clinically tested and third-party certified, which is a reason to choose Mitopure specifically.

Not yet assessedHigh confidence
MH
Mark Hyman
Cleveland Clinic Center for Functional Medicine
Caution / warning

not all urolithin A is clinically tested and third-party certified

Extracted claim

Not all urolithin A products are clinically tested and third-party certified, which is a reason to choose Mitopure specifically.

Not yet assessedHigh confidence