Mark Hyman
Physician, Functional Medicine
Cleveland Clinic Center for Functional Medicine
MD
“certain supplements may be helpful with people with insulin resistance and I use them my practice like lipoic acid magnesium chromium berberine vitamin D Omega-3s all really helpful”
Magnesium is used in clinical practice to help people with insulin resistance.
The claim that magnesium is used clinically for insulin resistance is partially supported by the available evidence. The meta-analysis of double-blind RCTs (PMID: 34836329) directly examined oral magn…
“ATP production and utilization is one of those and ATP is the energetic currency of our cells we need to make energy to survive”
Magnesium is essential for ATP production and utilization, which is the energetic currency of cells.
The claim that magnesium is essential for ATP production and utilization is a well-established biochemical principle, and several of the reviewed studies reference this role indirectly. For example, t…
“people aren't eating enough of their greens and they're not getting enough magnesium Greens and Beans Greens and Beans oats nuts almonds exactly things that aren't typically Staples of American diet which is 60% Ultra processed food”
People are not getting enough magnesium because they are not eating enough greens, beans, oats, nuts, and almonds, which are not staples of the American diet.
Several of the reviewed studies (e.g., PMID 33499378, 37242238, 34836329) reference widespread magnesium deficiency or insufficiency in Western/general populations and implicitly acknowledge low dieta…
“about 50% of the US population does not have adequate levels of magnesium 50% close to 50%”
Close to 50% of the US population does not have adequate levels of magnesium.
None of the 20 studies provided directly measure or report the prevalence of inadequate magnesium levels in the US general population. While several reviews (e.g., PMIDs 33499378, 37242238, 29793664)…
“zinc magnesium iodine potassium those are the big four that most of us are deficient in”
Magnesium is one of four key minerals that almost all people are deficient in, along with zinc, iodine, and potassium.
None of the 20 studies in the provided literature directly address the prevalence of mineral deficiencies in the general population across magnesium, zinc, iodine, and potassium simultaneously. While…
“you also need a lot of nutrients to metabolize your toxins things like folate zinc selenium magnesium manganes you need all the methylating B vitamins...these are all co-actors that basically power all those detox enzymes that are processing all the toxins”
Magnesium is needed as a co-factor to power detox enzymes that metabolize toxins.
None of the 20 studies in the provided literature directly address magnesium's role as a cofactor for detoxification enzymes metabolizing toxins. While the cardiovascular (PMID: 29793664) and metaboli…
“it's also essential for DNA repair enzymes they use it to repair damage to our DNA every time we make a new cell whether that's a skin cell or a liver cell or a blood cell”
Magnesium is essential for DNA repair enzymes, which repair damage to DNA during cell division and from external exposures.
None of the 20 published research sources listed address magnesium's role in DNA repair enzymes specifically. While the claim that magnesium serves as a cofactor for DNA repair enzymes is a recognized…
“if you don't get enough magnesium it's only going to those essential roles of ATP production and not the DNA repair enzymes”
When magnesium is insufficient, the body prioritizes it for ATP production at the expense of DNA repair enzymes, potentially contributing to long-term aging and health consequences.
None of the 20 listed studies directly address the specific mechanistic claim that magnesium deficiency causes the body to prioritize ATP production over DNA repair enzymes, or that this trade-off con…
“magnesium as Bruce would say is at the center of a chlorophyll molecule chlorophyll give plants their green color yeah so magnesium is very high in dark leafy greens”
Magnesium is at the center of the chlorophyll molecule, making it very high in dark leafy greens.
The expert's claim is a basic biochemistry fact — that magnesium is the central atom of the chlorophyll molecule and therefore dark leafy greens are rich in magnesium — which is well-established in ge…
“the magnesium RDA is about 350 to 400”
The magnesium RDA is approximately 350 to 400 (units not fully captured in transcript).
None of the 20 reviewed studies directly address or report the magnesium RDA value. While several studies (e.g., PMID 34836329, 33499378, 29793664) discuss magnesium supplementation and metabolism, no…
“about 50% of the US population does not have adequate levels of magnesium 50% close to 50%”
Close to 50% of the US population does not have adequate levels of magnesium.
None of the 20 provided studies directly measure the prevalence of magnesium insufficiency in the US general population. While several reviews (PMIDs 33499378, 37242238, 29793664) note that magnesium…
“zinc magnesium iodine potassium those are the big four that most of us are deficient in”
Magnesium is one of four key minerals that almost all people are deficient in, along with zinc, iodine, and potassium.
None of the 20 studies provided directly measure the prevalence of magnesium deficiency in the general population, which is what this claim requires. The studies focus on supplementation outcomes (sle…
“you also need a lot of nutrients to metabolize your toxins things like folate zinc selenium magnesium manganes you need all the methylating B vitamins...these are all co-actors that basically power all those detox enzymes that are processing all the toxins”
Magnesium is needed as a co-factor to power detox enzymes that metabolize toxins.
None of the 20 provided studies address magnesium's role as a cofactor for detoxification enzymes or hepatic metabolic pathways (e.g., Phase I/II enzymes such as cytochrome P450 or glutathione transfe…
“it's also essential for DNA repair enzymes they use it to repair damage to our DNA every time we make a new cell whether that's a skin cell or a liver cell or a blood cell”
Magnesium is essential for DNA repair enzymes, which repair damage to DNA during cell division and from external exposures.
None of the 20 provided studies directly examine or measure magnesium's role in DNA repair enzyme activity or DNA damage outcomes. The studies cover sleep (PMID 33865376), skeletal health (32972636),…
“you look at all your nutritional status right the B vitamins vitamin D vitamin E magnesium zinc copper CoQ10 lipoic acid Omega-3s”
Magnesium is among the nutritional markers assessed when evaluating factors that may affect the brain and overall health.
“if you don't get enough magnesium it's only going to those essential roles of ATP production and not the DNA repair enzymes”
When magnesium is insufficient, the body prioritizes it for ATP production at the expense of DNA repair enzymes, potentially contributing to long-term aging and health consequences.
“magnesium as Bruce would say is at the center of a chlorophyll molecule chlorophyll give plants their green color yeah so magnesium is very high in dark leafy greens”
Magnesium is at the center of the chlorophyll molecule, making it very high in dark leafy greens.
“three would be I think other supplementation strategies supplementation like creatine, carnitine, coq10”
Creatine is one of several supplementation strategies to enhance mitochondrial function and energy production.
The provided research consistently demonstrates that creatine supplementation enhances ATP recycling and energy availability in muscle and brain tissue, which is mechanistically linked to mitochondria…
“you can supplement with creatine or nutrients like lcarnitine CoQ10 that are integrated into the different mitochondrial cycle...you can make them more efficient”
Creatine can be supplemented to make mitochondria more efficient at producing energy.
The provided literature supports that creatine plays a key role in bioenergetics — particularly in recycling ATP in muscle and brain tissue — which is described in the RCT (PMID: 37968687) and the bra…
“all those enzymes require helpers. And all the helpers are vitamins and minerals or other compounds that are used by the body like creatine or carnitine and so forth. There's ways of actually supplementing to optimize mitochondrial function and health.”
Creatine is one of the compounds used as a helper in the mitochondrial respiratory chain, enabling energy production from food and oxygen.
The provided research supports that creatine plays a key role in energy metabolism, particularly in recycling ATP in muscle and brain tissue (PMID 37968687 describes creatine as 'an organic compound t…
“I had I used creatine... So, I would have like 50 grams for breakfast in a protein whey protein shake. I would put in creatine.”
Mark Hyman personally used creatine as part of his regimen to combat anabolic resistance and rebuild muscle after surgery, adding it to a morning whey protein shake.
The claim is a personal anecdote about using creatine to combat anabolic resistance and rebuild muscle post-surgery, which cannot be directly evaluated by the literature. However, the underlying ratio…
“I see advanced nutritional strategies which we talked about whether it's creatine NAD supplementation vitamin the B vitamins they they all great you know uh vitamin D we didn't talk about that but also has some great effects on mitochondria and immune cells”
Creatine is mentioned as part of advanced nutritional strategies that have great effects, particularly in the context of mitochondrial support.
The research literature broadly supports creatine as having meaningful physiological effects, particularly for muscle performance, body composition, and emerging evidence for brain health and cognitiv…
“those can only work if you take the bad damaged zombie mitochondria out from the real estate right...you can even potentiate the effects of things like NAD or creatine”
Creatine and similar mitochondrial boosters work better when damaged mitochondria are first cleared out, as they are most effective on well-functioning mitochondria.
None of the 20 published studies listed address the specific mechanistic claim that creatine or mitochondrial boosters are most effective when damaged mitochondria are first 'cleared out' (i.e., via m…
“when I have heart failure patients, I will give them a mitochondrial cocktail of supplements including CoQ10, carnitine, uh, creatine, ribos, lipoic acid, an acetylcysteine, the B vitamins and basically what happens is quite remarkable. They they prove their cardiac function by objective metrics like what we call ejection fraction”
Creatine is included in a mitochondrial cocktail of supplements that Hyman gives to heart failure patients, which improves cardiac function by objective metrics such as ejection fraction.
None of the 20 published studies in the provided list examine creatine supplementation for heart failure patients or assess cardiac outcomes such as ejection fraction. The research covers muscle perfo…
“omega-3 fats wild caught low mercury fatty fish is really important um like sardines mackerel enes and Herring flax seeds are great pasturage eggs can be great sources of Omega-3s”
Omega-3 fats from wild-caught, low-mercury fatty fish are an important component of a brain-healthy diet.
Several studies in the provided literature support a role for omega-3/fish oil supplementation in brain-related outcomes. The HELFIMED RCT (PMID: 29215971) found that a Mediterranean diet supplemented…
“vitamin D fish oil vitamin D 4000 fish oil one or two grams of the actual epha a multivitamin and high quality”
Fish oil is recommended at one to two grams of actual EPA as a core supplement alongside vitamin D and a multivitamin.
The research evidence supports the general utility of fish oil/omega-3 supplementation across multiple health domains (cardiovascular, mental health, pregnancy outcomes, PCOS, Alzheimer's disease), co…
“just take a multivitamin fish oil vitamin D magnesium and then you know maybe a broccoli pill yeah then there's a bunch of other things you could add to that list”
Fish oil, along with a multivitamin, vitamin D, and magnesium, is recommended as a basic daily supplement regimen at a low cost.
The provided literature offers some support for fish oil supplementation specifically, with studies examining its effects on cardiovascular markers (PMID 33741211, meta-analysis on arterial stiffness)…
“if you're eating you know Donuts all day you can take all the fish oil or vitamin D you want it's not going to do anything to you fix your risk of heart disease right so you have to look at everything together”
Taking fish oil alone won't fix heart disease risk if the overall diet is poor (e.g., eating donuts all day).
The expert's claim that fish oil alone cannot compensate for a poor overall diet is plausible and consistent with the broader literature, but none of the studies provided directly test the specific sc…
“trophic factors are essentially the fuel or the food or the ingredients that the brain needs to function including hormones and the right nutrients and vitamins and and fish oil all kinds of stuff that the brain actually needs to function”
Fish oil (omega-3s) is among the nutrients the brain needs to function properly.
The claim that omega-3s are nutrients the brain needs to function properly is a broad mechanistic statement with some indirect support from the provided literature. The HELFIMED RCT (PMID: 29215971) f…
“smokers with a high level of Omega-3 so they had a high omega-3 index of 8% they had the same mortality as non-smokers with a low omega-3 index”
Smokers with a high omega-3 index (8%) had the same mortality as non-smokers with a low omega-3 index.
None of the 20 studies in the provided literature base address the specific claim that smokers with a high omega-3 index (8%) have equivalent mortality to non-smokers with a low omega-3 index. The stu…
“having a low omega-3 index had the same mortality risk as smoking okay so we're talking about 90% of the American population is in that category”
Having a low omega-3 index carries the same mortality risk as smoking, and approximately 90% of the American population falls into this low omega-3 category.
None of the 20 published studies provided address the specific claims made by Dr. Hyman: (1) that a low omega-3 index carries equivalent mortality risk to smoking, or (2) that approximately 90% of Ame…
“people that have high omega-3 index 8% or more have a 5year increased life expectancy compared to people that have a 4% omega-3 index which is low”
People with a high omega-3 index of 8% or more have a 5-year increased life expectancy compared to people with a low omega-3 index of 4%.
None of the 20 published studies provided address the omega-3 index as a biomarker or its association with life expectancy. The claim references a specific epidemiological finding — that an omega-3 in…
“omega-3 fatty acids actually protect from any potential Mercury toxicity in the developing fetus”
Omega-3 fatty acids protect against potential mercury toxicity in the developing fetus, countering earlier advisories for pregnant women to avoid fish.
None of the 20 published studies provided address the specific claim that omega-3 fatty acids protect against mercury toxicity in developing fetuses. While two RCTs (PMIDs 34927195 and 36184023) exami…
“there's been studies looking at children that were born to mothers that had a high level of Omega-3 those children had scored higher on intelligence tests so IQ scores”
Children born to mothers with high omega-3 levels scored higher on IQ tests.
None of the 20 studies provided directly examine the relationship between maternal omega-3 levels and offspring IQ scores. The closest relevant study (PMID: 34927195) examines fish oil supplementation…
“you look at all your nutritional status right the B vitamins vitamin D vitamin E magnesium zinc copper CoQ10 lipoic acid Omega-3s”
Omega-3 levels (omega-3 index) should be assessed as part of a comprehensive brain health evaluation (cognoscopy).
None of the 20 studies provided directly evaluates the use of the omega-3 index as a diagnostic or screening biomarker in a 'cognoscopy' or comprehensive brain health evaluation framework. While one R…
“everybody this does not mean you can smoke and take your own fish oil pills don't get any ideas”
Taking fish oil and smoking is not advisable — this research result does not mean fish oil can cancel out the harms of smoking.
None of the 20 studies provided directly examine the interaction between fish oil supplementation and smoking, nor do any assess whether fish oil can mitigate smoking-related harms. The research cover…
“if you're eating you know Donuts all day you can take all the fish oil or vitamin D you want it's not going to do anything to you fix your risk of heart disease right so you have to look at everything together”
Taking fish oil alone won't fix heart disease risk if the overall diet is poor (e.g., eating donuts all day).
“trophic factors are essentially the fuel or the food or the ingredients that the brain needs to function including hormones and the right nutrients and vitamins and and fish oil all kinds of stuff that the brain actually needs to function”
Fish oil (omega-3s) is among the nutrients the brain needs to function properly.
“you look at all your nutritional status right the B vitamins vitamin D vitamin E magnesium zinc copper CoQ10 lipoic acid Omega-3s”
Omega-3 levels (omega-3 index) should be assessed as part of a comprehensive brain health evaluation (cognoscopy).
“omega-3 fats wild caught low mercury fatty fish is really important um like sardines mackerel enes and Herring flax seeds are great pasturage eggs can be great sources of Omega-3s”
Omega-3 fats from wild-caught, low-mercury fatty fish are an important component of a brain-healthy diet.
“the study that just came out about 10 days ago showing if you take the people who are low in vitamin D they have a much worse outcome in covid-19 than the people who have sufficient vitamin D”
Low vitamin D is associated with worse outcomes in COVID-19 compared to people with sufficient vitamin D levels, according to a recent study.
None of the 20 published research items provided address the relationship between vitamin D status and COVID-19 outcomes. The available studies cover vitamin D in contexts such as cardiovascular event…
“people who are low in vitamin D more likely to get Alzheimer's people who are sufficient vitamin D”
People who are low in vitamin D are more likely to get Alzheimer's disease.
None of the 20 published research abstracts provided address the relationship between vitamin D deficiency and Alzheimer's disease risk. The studies cover vitamin D in contexts such as cardiovascular…
“same thing in multiple sclerosis high vitamin D associated with better outcomes”
High vitamin D levels are associated with better outcomes in multiple sclerosis.
None of the 20 published research summaries provided addresses multiple sclerosis (MS) or the association between vitamin D levels and MS outcomes. While several studies examine vitamin D supplementat…
“if you want to be a vegetarian no problem make sure to check your homosysteine and your vitamin D and things like that”
Vegetarians following a brain-healthy diet should check their vitamin D levels (among other markers like homocysteine).
None of the 20 provided studies directly address the recommendation for vegetarians following a brain-healthy diet to monitor vitamin D levels or homocysteine. While several studies (PMIDs 33237064, 1…
“loss of nutrients like vitamin D uh loss of ngf or bdnf brain derived neurotrophic Factor these are all critical for keeping your brain functioning optimally”
Vitamin D is among the critical trophic/nutritional factors whose loss contributes to brain decline and is important for keeping the brain functioning optimally.
None of the 20 studies provided directly address vitamin D's role in brain function, cognitive decline, or neurological health. The closest relevant study (PMID: 37603263) reviews over-the-counter sup…
“there's type two which is atrophic and these are the people where they have low vitamin D pregnenolone progesterone estradiol testosterone you know on and on the critical supports for this nerve growth factor brain derived neurotrophic Factor B12”
In the atrophic type (type two) of Alzheimer's, low vitamin D is one of the key deficiencies to look for alongside low pregnenolone, progesterone, estradiol, testosterone, nerve growth factor, BDNF, and B12.
None of the 20 studies provided address Alzheimer's disease subtypes, the 'atrophic type two' classification framework, or the specific panel of deficiencies (pregnenolone, progesterone, estradiol, te…
“in Alzheimer's it's more likely to be things like MotoX sins or reduced vitamin D or reduced hormonal support or ngf or bdnf things like that”
Reduced vitamin D is one of the factors in Alzheimer's disease that is more likely to be causal compared to other neurodegenerative diseases.
None of the 20 published research articles provided address the relationship between vitamin D deficiency and Alzheimer's disease or neurodegenerative disease causality. The studies cover topics such…
“she had initially had a lot of a type two reduced estradiol progesterone no surprise she was 73 reduced vitamin D poor thyroid all those so all those were addressed um she then improved and she actually went from nine so she was in the ninth percentile on her initial cognitive scores she's now at the 97th percentile”
A patient with cognitive decline had reduced vitamin D (among other deficiencies), which was addressed as part of a comprehensive functional medicine approach, resulting in dramatic improvement in cognitive scores.
None of the 20 listed studies directly evaluate vitamin D supplementation as part of a comprehensive functional medicine protocol for cognitive decline or cognitive score improvement. The review on ov…
“you look at all your nutritional status right the B vitamins vitamin D vitamin E magnesium zinc copper CoQ10 lipoic acid Omega-3s”
Vitamin D is one of multiple nutrients checked as part of a comprehensive functional medicine assessment for cognitive decline, alongside B vitamins, vitamin E, magnesium, zinc, copper, CoQ10, lipoic acid, and omega-3s.
The expert's claim describes a multi-nutrient panel (vitamin D, B vitamins, vitamin E, magnesium, zinc, copper, CoQ10, lipoic acid, omega-3s) used in functional medicine assessments for cognitive decl…
“the beautiful thing about um protein is it's full of other good things like B vitamins amino acids glycine torine cysteine methine all critical”
Protein foods contain glycine along with other amino acids that are critical for health.
The claim that protein foods contain glycine along with other amino acids critical for health is broadly supported by mechanistic reviews in the provided literature. The glycine review (PMID: 28337245…
“I can tell you the best way to lower homoy um is 500 milligrams daily in a capsule form of trimethyl glycine TMG lots of great manufacturers that make it out there I make one symbiotica makes it Thorn pure encapsulations it's not an expensive nutrient if you have hyper homo symia that's a that's a must have supplement”
Trimethylglycine (TMG) at 500 mg daily in capsule form is the best way to lower homocysteine, and is a must-have supplement for people with hyperhomocysteinemia.
None of the 20 published research summaries provided address trimethylglycine (TMG) supplementation or its effects on homocysteine levels. While several studies discuss glycine (PMIDs 28337245, 378513…
“you don't want to be eating right before bed because it'll spike your insulin reduce your you know your growth hormone and your and your melatonin and so forth and so on”
Eating right before bed spikes insulin and reduces growth hormone and melatonin.
None of the 20 provided studies directly examine the effect of eating before bed on insulin, growth hormone, or melatonin levels. While several studies (PMIDs 33417003, 36235587, 40278958) discuss mel…
“as we get older like our thymus gland it will calcify and will Shel up and you lose melatonin and you lose epithin from the pineal gland”
As we age, the pineal gland calcifies and shrinks, causing loss of melatonin production.
None of the 20 studies listed directly address or test the mechanistic claim that pineal gland calcification and shrinkage with aging causes loss of melatonin production. While several reviews (e.g.,…
“my sleep I was on melatonin every year higher and higher higher Doses”
Mark Hyman was personally taking melatonin in ever-increasing doses every year to sleep, until using Epitalon.
The claim is a personal anecdote about Mark Hyman's individual behavior — escalating melatonin dosing followed by switching to Epitalon — which is not a scientific claim that can be evaluated against…
“do you know Epal turns on three genes of your pineal gland to make melatonin and my wife goes how come you're not taking melatonin anymore I like I don't need it I could sleep without it”
Epitalon turns on three genes of the pineal gland to make melatonin, which allowed Mark Hyman to stop needing melatonin supplementation.
None of the 20 published studies in the provided literature address Epitalon (epithalon/epitalon peptide) or its purported mechanism of activating pineal gland genes to stimulate endogenous melatonin…
“theanine is an amino acid that can be helpful”
Theanine is an amino acid that can be helpful for actively managing stress.
Multiple systematic reviews (PMIDs 31758301, 39633316) and RCTs (PMID 38975711) provide direct evidence that L-theanine supplementation is associated with reductions in stress and anxiety-like symptom…
“other things can be helpful like theanine Gaba 5htp”
Theanine can be helpful as a sleep/wind-down aid.
The most directly relevant evidence is a systematic review and meta-analysis (PMID: 40056718) specifically examining L-theanine's effects on sleep outcomes across multiple RCTs, which provides the str…
“actively managing your stress is important and not with drugs but things like adaptogens riola ashwagandha Jin sing Siberian Jin sing all can be helpful”
Ashwagandha, as an adaptogen, can be helpful for actively managing stress.
Multiple RCTs (e.g., PMID 31517876, a 60-day double-blind placebo-controlled study, and PMID 37740662, a 12-week RCT in overweight adults with self-reported stress) demonstrate statistically significa…
“just as you would have scurvy if you didn't have enough vitamin C”
Vitamin C deficiency, if severe enough, causes scurvy — used as an analogy for how nutrient deficiencies manifest as disease.
“making sure your nutrients are okay so you're taking your multivitamin getting your zinc you're getting your cenum you're getting your vitamin C but there are the whole cocktail of things that help support immunity”
Vitamin C is mentioned as one of the key nutrients to ensure adequate intake as part of an immune-supportive regimen, alongside zinc and selenium.
“if you don't have enough vitamin C and you're a sailor you get scurvy right”
Classic severe vitamin C deficiency causes scurvy, historically seen in sailors, as an example of a short-term nutrient deficiency disease.
“quite a bit of people are not getting enough vitamin C something like 30 or 40 40% 40% or something like that I'm not getting enough vitamin C yeah I heard that 10% are deficient the level that would cause scurvy in America that's unbelievable”
Approximately 40% of people are not getting enough vitamin C, and around 10% are deficient at levels that would cause scurvy in America.
“just not eating any ve any vegetables or or fruits because vitamin C is also in vegetables it's not just in fruits”
Vitamin C is found in vegetables as well as fruits, and not eating any vegetables or fruits can lead to vitamin C deficiency.
“As opposed to vitamin C, which”
Unlike fat-soluble vitamins, vitamin C does not need to be taken with food or fat for absorption.
“you take your vitamin D, you have to have it with some fat, right? As opposed to vitamin C”
Vitamin C does not need to be taken with fat, unlike vitamin D.
“it only takes like 60 milligrams of Vitamin C to cure scurvy which is a deadly disease if you don't have enough vitamin C”
It only takes approximately 60 milligrams of vitamin C to cure scurvy, a deadly disease caused by vitamin C deficiency.
“10% of Americans don't have enough vitamin C to prevent scy which is mindblowing right which because they're eating Ultra processed food and they don't get any green vegetables and they don't get any you know fruit”
10% of Americans do not have enough vitamin C to prevent scurvy, largely because they eat ultra-processed food and lack green vegetables and fruit.
“you also need a lot of nutrients to metabolize your toxins things like folate zinc selenium magnesium manganes you need all the methylating B vitamins...these are all co-actors that basically power all those detox enzymes that are processing all the toxins”
Selenium is a nutrient needed as a co-factor to power detox enzymes that process toxins in the body.
“widespread deficient you know Iron zinc selenium a lot of things that iodine I mean it just I see this all the time in our testing my function health and I'm like kind of shocked”
Selenium deficiency is widespread in the population and is frequently underdiagnosed, as observed through micronutrient testing in a cohort of 110,000 people.
“I think a multivitamin is a really good insurance because you know there's so selenium Boron Boron yeah there's you know the the B vitamins you know you're getting there's vitamin A there's so many different micronutrients and it really covers a lot of the bases”
A high-quality multivitamin is recommended partly because it contains selenium along with many other micronutrients, helping to cover common nutrient gaps.
“you also need a lot of nutrients to metabolize your toxins things like folate zinc selenium magnesium manganes you need all the methylating B vitamins...these are all co-actors that basically power all those detox enzymes that are processing all the toxins”
Selenium is a nutrient needed as a co-factor to power detox enzymes that process toxins in the body.
“widespread deficient you know Iron zinc selenium a lot of things that iodine I mean it just I see this all the time in our testing my function health and I'm like kind of shocked”
Selenium deficiency is widespread in the population and is frequently underdiagnosed, as observed through micronutrient testing in a cohort of 110,000 people.
“you would find all of the other Trace metal Boron zinc selenium manganese malum you find all of these that that're not the sort of headline minerals that most people think about”
Selenium is one of many trace minerals found naturally in running streams that are absent from most electrolyte supplements.
“people might be taking 10 different supplements and they like they say, they all might have selenium in them, correct? And then you're getting toxic doses of selenium 100%. And you don't know that cuz you're not adding it all up.”
Taking multiple supplements that each contain selenium can result in toxic doses of selenium if you are not tracking the total amount across all products.
“there's some other examples like selenium that bru has published and showed there are proteins that have a stronger binding to vitamin K1 that are important for coagulation so these are proteins in the liver um versus for example other proteins that stay in circulation and are activating proteins that are important for calcium signaling and trafficking”
There are selenium-dependent proteins that show differential binding affinity, with some having stronger binding to certain nutrients (like vitamin K1) for acute essential functions such as coagulation, versus other proteins important for calcium signaling.
“people might be taking 10 different supplements and they like they say, they all might have selenium in them, correct? And then you're getting toxic doses of selenium 100%. And you don't know that cuz you're not adding it all up.”
Taking multiple supplements can result in toxic doses of selenium because people don't add up the total selenium content across all their products.
“you need a lot of other minerals and vitamins with magnesium to make them work like B6 vitamin D selenium uh so you need those all to kind of work together as a team”
Selenium is one of several nutrients needed alongside magnesium for them to work properly together.
“you want to talk about a pandemic selenium selenium thyine um um and and you know to to help this this this outer ring deize in in the liver which is where two-thirds of it comes from and the balances in the gut and a little bit in the periphery but the point is that a nutrient deficiency can lead to a hormone deficiency that gets diagnosed as a as organ”
Selenium deficiency may be pandemic and selenium is needed to support the conversion (deiodination) of thyroid hormones, primarily in the liver, which can otherwise lead to a nutrient deficiency being diagnosed as a hormone or organ deficiency.
“if it came down to one or two nutrients D3 and K2 would be up there methyl folate would be right at the absolute top of the chart for me”
D3 and K2 are among the most important nutrients, ranking at the top alongside methylfolate.
“my favorite vitamin D is something called vitamin D Supreme it has vitamin K2 as well including the mk7 form which is important for your heart”
Hyman personally takes a vitamin D supplement called Vitamin D Supreme, which contains vitamin K2 including the MK-7 form, which is important for heart health.
“urolithin A has this remarkable ability to activate mitophagy. Mitophagy is not sort of the as the term implies, it's eating mitochondria, but it doesn't eat them discriminately. It eats the old, defective mitochondria”
Urolithin A activates mitophagy, which selectively removes old and defective mitochondria.
“not all urolithin A is clinically tested and third-party certified”
Not all urolithin A products are clinically tested and third-party certified, which is a reason to choose Mitopure specifically.
“which I by by the way take every day because the literature is impressive on it.”
Mark Hyman takes urolithin A every day because the literature on it is impressive.
“only 30 to 40% of people can produce urolithin A naturally”
Only 30 to 40% of people can produce urolithin A naturally.
“one of the most promising compounds to do this is something called urolithin A”
Urolithin A is one of the most promising compounds for targeting mitochondrial decline for healthy aging.
“urolithin A has this remarkable ability to activate mitophagy. Mitophagy is not sort of the as the term implies, it's eating mitochondria, but it doesn't eat them discriminately. It eats the old, defective mitochondria”
Urolithin A activates mitophagy, which selectively removes old and defective mitochondria.
“it's a natural molecule that your body can make when you have the right gut bacteria to convert compounds found in foods like pomegranate and walnuts”
Urolithin A is a natural molecule the body can produce when the right gut bacteria convert compounds found in foods like pomegranate and walnuts.
“not all urolithin A is clinically tested and third-party certified”
Not all urolithin A products are clinically tested and third-party certified, which is a reason to choose Mitopure specifically.
“science has already shown that urolithin A supports muscle and skin health”
Urolithin A supports muscle and skin health, as already shown by science.
“A new clinical trial in healthy, middle-aged adults found that just 4 weeks of supplementing with 1,000 mg of urolithin A, which is what I take every day, led to a more youthful immune profile. T cells became more responsive, the immune system got better at clearing threats, markers of inflammation, they all went down, all while mitochondrial energy production improved across the board.”
A new clinical trial found that 4 weeks of supplementing with 1,000 mg of urolithin A daily led to a more youthful immune profile in healthy middle-aged adults, with T cells becoming more responsive, the immune system getting better at clearing threats, markers of inflammation going down, and mitochondrial energy production improving.
“1,000 mg of urolithin A, which is what I take every day... I take it every single day”
Mark Hyman personally takes 1,000 mg of urolithin A (as Mitopure) every single day.
“which I by by the way take every day because the literature is impressive on it.”
Mark Hyman takes urolithin A every day because the literature on it is impressive.
“we don't make, for example, one of these postbiotics called urolithin A, so we make it from pomegranate or other ellagitannins that are in, you know, walnuts or berries or whatever.”
Urolithin A is a postbiotic that humans do not make themselves; it is produced by gut microbiome metabolism of ellagitannins found in pomegranate, walnuts, berries, and similar foods.
“these compounds are not acting by themselves. They are actually metabolized by your microbiome. And that's really And the products of that is made by by your microbiome is is called urolithin A.”
Ellagitannins from pomegranate are not acting by themselves; they are metabolized by the gut microbiome, and the product of that metabolism is urolithin A.
“only about 35% of people whose microbiome cuz remember, all of our microbiomes are different. And some 60% of people's microbiome is not able to make that conversion.”
Only about 35% of people have a microbiome capable of converting ellagitannins into urolithin A; approximately 60% of people's microbiomes cannot make that conversion.
“urolithin A that is the result of a input from a pro a food product from a from a plant from a pomegranate juice that gets transformed by a fraction of us into a product that has immense benefit. So, company was founded based on this. Amazentis actually sells this product.”
Urolithin A, derived from pomegranate juice via microbiome transformation, has immense benefit, and a company (Amazentis) was founded to sell it as a product.
“we don't make, for example, one of these postbiotics called urolithin A, so we make it from pomegranate or other ellagitannins that are in, you know, walnuts or berries or whatever.”
Urolithin A is a postbiotic that humans do not make themselves; it is produced by gut microbiome metabolism of ellagitannins found in pomegranate, walnuts, berries, and similar foods.
“these compounds are not acting by themselves. They are actually metabolized by your microbiome. And that's really And the products of that is made by by your microbiome is is called urolithin A.”
Ellagitannins from pomegranate are not acting by themselves; they are metabolized by the gut microbiome, and the product of that metabolism is urolithin A.
“Steven canine showed years ago you can ramp those ketones up to 1 two three Millar beta hydroxy butyrate and you can you can address that energy gap”
Research by Steven Cunnane showed that ramping ketones up to 1–2–3 mM beta-hydroxybutyrate can address the brain's critical energy gap seen in Alzheimer's disease.
“you have a critical energy gap that you need to change you need to address that Gap and the best way to do it of course is with ketosis”
Ketosis (and ketones) is the best way to address the critical energy gap in the brain associated with Alzheimer's disease.
“when we used to grow the neurons basically using a ketogenic diet you can increase the way the brain uses energy and make it basically have more energy by feeding it fat instead of sugar and carbs”
Feeding the brain fat instead of sugar and carbs via a ketogenic diet can increase brain energy utilization and give it more energy.
“sugar damages your ability to support your synapsis so you got to address with ketones you got to address the energy you've got to address the insulin sensitivity”
Sugar damages the ability to support synapses, so ketones must be used to address brain energy in Alzheimer's.
“because getting into ketosis is so critical for supporting brain energetics we tell them just start by taking some exogenous ketones do it for a couple of months no problem because we need to get that energy up”
Taking exogenous ketones as a supplement for a couple of months can support brain energetics, particularly for those who find it difficult to achieve ketosis through diet alone (e.g., vegans or vegetarians).
“the third area is energetics and that's oxygenation blood flow mitochondria and ketones the ability to have a substrate to burn”
Ketones are one of four critical areas for brain energetics, serving as a substrate the brain can burn.
“when you have cognitive decline you've lost both of those so you are literally starving your brain you've lost the glucose because you now have insulin resistance you've lost the ketones because your insulin is high and it's preventing you from making the ketones”
In cognitive decline, the brain loses the ability to burn both glucose and ketones, effectively starving the brain; high insulin levels prevent endogenous ketone production.
“we encourage people to measure their ketones whether you like to do it by finger stick or you can do it by breathalizer to get in the appropriate Ketone range”
Patients are encouraged to measure their ketones (via finger stick or breathalyzer) to confirm they are in the appropriate ketone range.
“Steven canine showed years ago you can ramp those ketones up to 1 two three Millar beta hydroxy butyrate and you can you can address that energy gap”
Research by Steven Cunnane showed that ramping ketones up to 1–2–3 mM beta-hydroxybutyrate can address the brain's critical energy gap seen in Alzheimer's disease.
“you have a critical energy gap that you need to change you need to address that Gap and the best way to do it of course is with ketosis”
Ketosis (and ketones) is the best way to address the critical energy gap in the brain associated with Alzheimer's disease.
“when we used to grow the neurons basically using a ketogenic diet you can increase the way the brain uses energy and make it basically have more energy by feeding it fat instead of sugar and carbs”
Feeding the brain fat instead of sugar and carbs via a ketogenic diet can increase brain energy utilization and give it more energy.
“sugar damages your ability to support your synapsis so you got to address with ketones you got to address the energy you've got to address the insulin sensitivity”
Sugar damages the ability to support synapses, so ketones must be used to address brain energy in Alzheimer's.
“typically we don't recommend for example coconut oil MCT oil we recommend if you want to take some want to get into ketosis exogenously just take some exogenous Ketone take Ketone salts take Ketone Esters those sorts of things you can do that a couple of times a day and get nice spikes in your Ketone levels”
For individuals who are APOE4 positive, MCT oil and coconut oil are not recommended; instead, exogenous ketone salts or ketone esters are recommended to achieve ketosis, taken a couple of times a day for nice spikes in ketone levels.
“MMP levels were going down and so that's a marker of inflammation that's a marker of inflammation that's also a marker of you know how much collagen you're going to degrade”
In randomized trials using a topical mitochondria-targeting formulation, MMP levels went down, indicating reduced collagen degradation — described as a marker of inflammation and an indicator of how much collagen will be degraded.
“collagen is the protein that keeps your skin together and there are enzymes called matrix metalloproteinases MMPs that degrade collagen that just go shoot up with aging and what top we saw in these trials was that MMP levels were going down and so that's a marker of inflammation that's a marker of inflammation that's also a marker of you know how much collagen you're going to degrade”
Matrix metalloproteinases (MMPs), enzymes that degrade collagen, increase with aging, and MMP levels going down is a marker of reduced inflammation and less collagen degradation.
“bone broth has a lot of gut healing components in it collagen and very anti-inflammatory”
Bone broth contains collagen and is gut-healing and anti-inflammatory.
“we we know that it improves um uh collagen elastin fibrin um we also know that that's all your connective tissue that's your connective tissue which is often very inflamed and that causes pain or dysfunction”
Red light and near-infrared light therapy improves collagen, elastin, and fibrin (connective tissue), which is often inflamed and causes pain or dysfunction.
“there's lots of uh studies on the proliferation of collagen elastin and fibrin”
There are many studies on the proliferation of collagen, elastin, and fibrin from red light therapy.
“you might have some pleasing effects on the skin like you know um improve collagen lasting fibrin in the surface of your skin you might have some reduction of fine lines and wrinkles”
Superficial red light can improve collagen, elastin, and fibrin at the surface of the skin, with some reduction of fine lines and wrinkles.
“one device that upstages the mitochondria that improves collagen elastin and fibrin in the skin that improves angiogenesis the formation of new blood vessels beneath the skin”
Red light bed therapy improves collagen, elastin, and fibrin in the skin, as well as angiogenesis.
“the masks for the face are great for collagen and elastin in your skin fiber in skin”
Red light masks for the face are good for collagen and elastin in the skin.
“this is our natural killer cells um collagen elastin fibrin in our skin a lot of marketing gimmicks have allowed us to think that we can Target direct protein like we can eat collagen and it shows up ex...”
Collagen, along with elastin and fibrin, is a protein that cannot simply be assembled by eating collagen directly — people need adequate amino acid building blocks to produce these proteins.
“DHEA sulfate this is a hormone that looks at your adrenal function adrenal function is connected to your sex hormones but often as we're under stress as we age our DHA levels go down and we tend to age faster we tend to have more fatigue we tend to have less libido we tend to have other issues”
DHEA sulfate is a hormone that reflects adrenal function, which is connected to sex hormones; as people experience stress and aging, DHEA levels decline, leading to faster aging, more fatigue, less libido, and other issues.
“so checking your your dhaa level is really important because that tells you where you are in”
Checking your DHEA level is important because it tells you where you are in terms of adrenal and hormonal health.
“you restore the DHEA level you restore the hormones very often”
Restoring DHEA levels can often restore hormone levels more broadly.
“high shbg or low DHEA those three are are critical to having um healthy levels of testosterone”
Low DHEA is one of three critical factors causing low testosterone levels, alongside low LDL cholesterol and nutrient deficiencies such as vitamin D3.
“if you see somebody that has low double digit levels of DHEA right um in highend which is actually usually caused by stress right yeah it's very often caused by stress it's an easy supplement to take um you you supplement them with DHEA and then all of a sudden the hormone production starts again”
Low double-digit DHEA levels, which are often caused by stress, can be treated with DHEA supplementation, after which hormone production resumes.
“they gave human growth hormone and that form in DHEA and it it improved their thy the thymus improved it was only a men so they're going to do another trial”
A study gave human growth hormone and DHEA together and found it improved the thymus.
“found she had a really high level of something called methon acid and homocysteine which are things that most doctors don't check but reflect your status of B12 which is methanic acid and homocysteine which is the folate and even B6 so I basically gave her B12 shots high doses of methyl folate...and she called me back and was doing amazing and all of her symptoms had gone away”
High levels of methylmalonic acid and homocysteine reflect deficient B12 and folate status, and correcting these deficiencies with B12 shots and methylfolate resolved a patient's depression and severe cognitive decline.
“the critical supports for this nerve growth factor brain derived neurotrophic Factor B12 all these things it takes as you know it takes a lot to keep a brain functional”
B12 is one of the critical supports needed to keep the brain functional, particularly in atrophic-type neurodegeneration.
“you also need a lot of nutrients to metabolize your toxins things like folate zinc selenium magnesium manganes you need all the methylating B vitamins folate B12 B6 um and you need these are all co-actors that basically power all those detox enzymes that are processing all the toxins”
B12, along with folate and B6, is needed as a co-factor to power detox enzymes that process toxins.
“the ones that are really causing Havoc are you know deficiencies and you know the methylation nutrient it's like the B vitamins folate B6 B12 deficiencies”
Deficiencies in methylation nutrients including B12, folate, and B6 are among the most common and impactful nutrient deficiencies causing problems in the country.
“It inhibits B12 absorption which is critical for so many functions that can cause depression, dementia, neurologic issues. People don't know this”
Long-term use of proton pump inhibitors (PPIs) inhibits B12 absorption, which is critical for many functions, and can cause depression, dementia, and neurologic issues.
“We check your level of B vitamins like homoyine and methylonic acid which measure B12, folate, B6 effectiveness.”
Methylmalonic acid and homocysteine can be tested to measure the effectiveness of B12, folate, and B6, as part of a 'test, don't guess' approach to identifying nutrient deficiencies.
“We check your level of B vitamins like homoyine and methylonic acid which measure B12, folate, B6 effectiveness.”
Measuring methylmalonic acid and homocysteine can assess B12 effectiveness as part of a functional medicine workup.
“if you taking an acid blocking drug you're going to prevent B12 absorption and even magnesium and and zinc absorption”
Acid-blocking drugs prevent B12 absorption.
“rather than just taking a drug to suppress stomach acid which we desperately need to digest our food to absorb minerals to absorb B12 to digest protein”
Stomach acid is needed to absorb B12, and drugs that suppress stomach acid interfere with this absorption.
“some of the nutritional deficiencies that are pretty common that any family doc could do would be vitamin B12 and d”
Vitamin B12 deficiency is a common nutritional deficiency seen in patients with depression that is modifiable.
“vitamin B12 is a pet peeve of mind because our normal range the lab slips might say 220 to 1100 and nobody feels well with a level of 220 so times we've treated people with severe depression that we're told by their PCP they have normal B12”
The conventional lab normal range for B12 (220–1100) is misleading because nobody feels well at a level of 220, and patients with severe depression have been told they have normal B12 when they do not.
“a B12 shot and they're on a different path”
Giving a B12 shot to patients with low-normal B12 levels who have severe depression can put them on a different (improved) path.
“you want to make sure that you reduce your uh drugs if you can or switch to different drugs or are not that are not depleting the the nutrients or that you actually take the nutrients as a replacement”
If taking nutrient-depleting drugs such as acid blockers, patients should either switch drugs or take the depleted nutrients (including B12) as replacement.
“zinc magnesium iodine potassium those are the big four that most of us are deficient in”
Potassium is one of the key minerals that almost all people are deficient in.
“zinc magnesium iodine potassium those are the big four that most of us are deficient in”
Magnesium is one of the key minerals that almost all people are deficient in.
“I think it's something like 96% of the US population doesn't meet the adequate intake for potassium it's essentially everyone”
Approximately 96% of the US population does not meet the adequate intake for potassium — essentially everyone is deficient.
“potassium is a big one because it's so important for the sodium potassium pump which plays a role in blood pressure”
Potassium is important for the sodium-potassium pump, which plays a role in blood pressure regulation.
“when you're talking about too much sodium and not enough potassium it's really exacerbating without not getting enough potassium aspect right because that ratio is so important”
Too much sodium combined with not enough potassium exacerbates blood pressure problems, because the ratio of potassium to sodium is critically important.
“our potassium intake is as Hunter together should be 10 to one potassium to sodium now it's the other way around”
The ancestral potassium-to-sodium ratio should be 10 to 1, but in modern diets it has reversed.
“pottassium does play an important role in regulating blood pressure”
Potassium plays an important role in regulating blood pressure.
“so does magnesium too so does magnesium so does magnesium it's a relaxation mineral”
Magnesium also plays a role in regulating blood pressure and is described as a 'relaxation mineral.'
“it's not like salt is bad we need salt it's just it's all the salt added by corporations to your food that make you palatable...and you need to actually not get as much sodium which is what we're eating all Ultra processed food”
Salt itself is not bad — people need sodium — but the problem is excessive sodium added by corporations to ultra-processed foods, combined with insufficient potassium from plants.
“that's where you get your you know potassium which is from you know plants”
Potassium is obtained from plants, and a diet rich in plants is the way to address potassium deficiency.
“through the things that are the most common deficient in in our in our country right Omega-3s vitamin D magnesium and there's others right”
Magnesium deficiency is one of the most common nutrient deficiencies causing widespread harm.
“if you're sweating a lot like I exercise and I sweat a lot I I make sure I take electrolytes because I want to replenish my magnesium”
Mark Hyman takes electrolytes when exercising and sweating a lot to replenish magnesium.
“I take a mineral salt every morning um I take one called Baja gold sea salt but a mineral salt like a Celtic salt or a B could you use electrolytes is that kind um I use that as my electrolyte”
Hyman uses a mineral salt (Baja Gold sea salt) as his electrolyte source, noting Celtic salt or similar mineral salts could serve the same purpose.
“zinc magnesium iodine potassium those are the big four that most of us are deficient in”
Potassium is one of the key minerals that almost all people are deficient in.
“zinc magnesium iodine potassium those are the big four that most of us are deficient in”
Magnesium is one of the key minerals that almost all people are deficient in.
“so does magnesium too so does magnesium so does magnesium it's a relaxation mineral”
Magnesium also plays a role in regulating blood pressure and is described as a 'relaxation mineral.'
“I think it's something like 96% of the US population doesn't meet the adequate intake for potassium it's essentially everyone”
Approximately 96% of the US population does not meet the adequate intake for potassium — essentially everyone is deficient.
“potassium is a big one because it's so important for the sodium potassium pump which plays a role in blood pressure”
Potassium is important for the sodium-potassium pump, which plays a role in blood pressure regulation.
“that's where you get your you know potassium which is from you know plants”
Potassium is obtained from plants, and a diet rich in plants is the way to address potassium deficiency.
“when you're talking about too much sodium and not enough potassium it's really exacerbating without not getting enough potassium aspect right because that ratio is so important”
Too much sodium combined with not enough potassium exacerbates blood pressure problems, because the ratio of potassium to sodium is critically important.
“our potassium intake is as Hunter together should be 10 to one potassium to sodium now it's the other way around”
The ancestral potassium-to-sodium ratio should be 10 to 1, but in modern diets it has reversed.
“if you're sweating a lot like I exercise and I sweat a lot I I make sure I take electrolytes because I want to replenish my magnesium”
Mark Hyman takes electrolytes when exercising and sweating a lot to replenish magnesium.
“pottassium does play an important role in regulating blood pressure”
Potassium plays an important role in regulating blood pressure.
“it's not like salt is bad we need salt it's just it's all the salt added by corporations to your food that make you palatable...and you need to actually not get as much sodium which is what we're eating all Ultra processed food”
Salt itself is not bad — people need sodium — but the problem is excessive sodium added by corporations to ultra-processed foods, combined with insufficient potassium from plants.
“the key ones that almost all of us are deficient as you know in zinc and and zinc has become a huge issue because of covid-19”
Zinc is one of the key minerals that almost all of us are deficient in.
“so many of the people who are deficient in zinc are reduced and have an increased poor outcome increased risk for having a poor outcome from covid-19”
People deficient in zinc have an increased risk of poor outcomes from COVID-19.
“zinc magnesium iodine potassium those are the big four that most of us are deficient in”
Zinc is one of the big four minerals — along with magnesium, iodine, and potassium — that most people are deficient in.
“you look at all your nutritional status right the B vitamins vitamin D vitamin E magnesium zinc copper CoQ10 lipoic acid Omega-3s”
Zinc is among the nutritional factors to assess when evaluating brain and Alzheimer's risk, alongside B vitamins, vitamin D, magnesium, copper, CoQ10, lipoic acid, and Omega-3s.
“you look at all your nutritional status right the B vitamins vitamin D vitamin E magnesium zinc copper CoQ10 lipoic acid Omega-3s”
CoQ10 is listed as a nutritional marker worth measuring when assessing overall health status, alongside other vitamins and nutrients.
“taking uh nutritional supplements that can optimize your mitochondria like the Mito Q or CoQ10 or other things that we suggested for you can be really really effective”
Nutritional supplements that optimize mitochondria, such as Mito Q or CoQ10, can be very effective for optimizing energy production, particularly during high-performance endurance activities.
“there's many of those that you need more of depending on your state of health or what's going on like CoQ10 if you're on a statin”
CoQ10 is a conditionally essential nutrient — one you need more of depending on your state of health — particularly if you are on a statin.
“doing nutrition testing on tens of thousands of people and deep analysis of minerals and vitamins and antioxidant levels and oxidative stress and CoQ10, all the things that people normally don't look at. It's so widespread like nutrient deficiency is so widespread in America.”
CoQ10 levels are commonly tested as part of comprehensive nutritional analysis, and nutrient deficiencies including CoQ10 are widespread in America.
“you need to have appropriate probiotics to support your microbiome”
Appropriate probiotics are needed to support the microbiome as part of an optimal biochemistry for brain health and preventing cognitive decline.
“we actually probably do have a normal brain microbiome and we're going to have to have probiotics for our brain at some point cogn notics right cogn notics yeah there we go”
Probiotics for the brain ('cognotics') may eventually be needed, given the emerging understanding that the brain likely has its own normal microbiome.
“mitochondrial supplements that are used to improve mitochondrial function, whether CoQ10 or NAD or NMN or the B vitamins”
NMN is a mitochondrial supplement used to improve mitochondrial function.
“I take nmn form of a younger NN about 1,000 milligrams a day to support NAD production again this is really critical for activating longevity switches”
Mark Hyman personally takes NMN at 1,000 milligrams per day to support NAD production, which he considers critical for activating longevity switches.
“I'm quite convinced there's such a thing as a lithium deficiency disorder... lithium is a natural element and it's essential for human health in small amounts”
The expert believes there is such a thing as a lithium deficiency disorder, arguing lithium is an essential nutrient needed for human health in small amounts
“lowd dose nutritional lithium kind of was the answer um they have a family history of major mental illness they're aggressive they're irritable and just small amounts nutritional lithium was enough to kind of keep them um behaving”
Low-dose nutritional lithium helped aggressive, impulsive children with ADHD-like behavior stay in school and control violent impulses
“thousands of hair tests of kids with lithium when I started you know I'd get like 25 30% undetectable lithium in the hair now I'm seeing 75%”
Undetectable lithium levels in children's hair tests have increased dramatically from 25–30% to 75% over the expert's career, suggesting widespread nutritional lithium deficiency
“the amount of lithium in the tap water in our drinking water uh varied geographically...one part of Texas High lithium guess what they had low rates of suicide and mental illness another part of Texas had low lithium they had high rates...we've done these studies all around the globe and the amount of lithium in the tap water predicts exactly rates of suicide High lithium low rates”
Higher lithium levels in tap water are associated with lower rates of suicide and mental illness, based on studies conducted globally
“lithium sounds like it's something you treat bipolar patients with it's something that's we learned in medical school is toxic you have to measure blood levels and you don't want to take too much of it and you can get thyroid suppression...the difference between therapeutic uh medication pharmacologic Doses and nutritional lium therapy”
Nutritional lithium (low-dose) is distinct from pharmacologic lithium used to treat bipolar disorder, which requires blood level monitoring and carries risks like thyroid suppression
“I don't know if it's the bottled water we're not getting lithium from our natural tap water sources or other environmental things binding it but I I believe that's a factor”
Declining lithium in drinking water—possibly due to filtered or bottled water replacing tap water—is a contributing factor to the rise in child mental health problems
“Leucine is important for muscle health”
Leucine is important for muscle health.
“if you use animal protein, you're going to get a much more concentrated protein at a lower calorie count and also with higher levels of leucine, which is the amino acid you need to actually make muscle.”
Animal protein contains higher levels of leucine compared to plant protein, and leucine is the amino acid needed to make muscle.
“The most important is the resistance training input, the mechanical input, and then the protein input. Yeah. >> Primarily leucine.”
Leucine is primarily the key amino acid input for muscle building, alongside resistance training.
“leucine was the rate limiting amino acid for turning on the switch that starts you to build muscle.”
Leucine is the rate-limiting amino acid for turning on the switch that initiates muscle building.
“I might have a scoop of a whey protein shake, which is has about 20 g of protein, 2 and 1 half grams of leucine, but that's not enough for me because, you know, I'm burn the candle at both ends and I'm I'm training hard. So I'll add in a scoop of essential amino acids.”
Mark Hyman personally consumes a whey protein shake containing 2.5 grams of leucine, but notes that amount is not enough for him given his training demands, so he adds essential amino acids.
“we eat for the branch chain amino acids amino acids which are Lucine isol leucine and veine that all come in the right amounts to feed skeletal muscle”
Leucine, isoleucine, and valine are branched-chain amino acids that come in the right amounts to feed skeletal muscle.
“you can get epitalon spray which is actually nasal spray no under the tongue under the tongue normally you have to inject”
Epithalon is available as an under-the-tongue spray, as an alternative to injection
“is this something you take every day is it something you take cavison wants you to cycle it and so I have made my patients”
Epithalon is something Hyman has his patients take, and it is cycled rather than taken every day
“which is sad because the FDA has this on the chopping blocks there too uh in terms of banning peptides”
The FDA is considering banning epithalon along with other peptides
“if you can get from Russia the original one Cav sure there's not a lot of Commerce Going Back in Forth with Russia China through China yeah yeah”
The original epithalon from Russia (Khavinson's formulation) is preferred, though access is difficult due to limited commerce with Russia
“I basically gave her B12 shots high doses of methyl folate which is a particular kind saw she had some genes that made her need a special kind of folate and she called me back and was doing amazing and all of her symptoms had gone away”
High doses of methyl folate were given to a patient with elevated homocysteine and cognitive decline, and her symptoms resolved.
“she had some genes that made her need a special kind of folate”
Some individuals have genetic variants that require a special form of folate (methyl folate) rather than regular folate.
“homocysteine which are things that most doctors don't check but reflect your status of B12 which is methanic acid and homocysteine which is the folate and even B6”
Homocysteine levels reflect folate status and are a marker most doctors don't check.
“you also need a lot of nutrients to metabolize your toxins things like folate zinc selenium magnesium manganes you need all the methylating B vitamins folate B12 B6 um and you need these are all co-actors that basically power all those detox enzymes that are processing all the toxins”
Folate is one of the nutrients needed to metabolize toxins, acting as a co-factor that powers detox enzymes.
“he used a media that didn't have folate and uh all of a sudden um he started noticing all these double stranded breaks in DNA...DNA double shed brakes and D DNA are the precursor to um basically on oncogenic mutation cancer”
Research showed that cell media lacking folate caused double-stranded DNA breaks, which are precursors to oncogenic mutations and cancer.
“he decided to do some animal work well let's see what happens if we don't if we deprive you know rodents of folate and sure enough widespread DNA damage just completely you know and DNA double shed brakes and D DNA are the precursor to um basically on oncogenic mutation cancer”
Animal studies depriving rodents of folate produced widespread DNA damage and double-stranded DNA breaks, which are precursors to cancer.
“he had found some humans um that were low and folate and did some experiments as well found a similar thing gave them back the folate DNA double stranded brakes went away”
In human subjects who were low in folate, DNA double-stranded breaks were observed, and restoring folate caused those breaks to go away.
“folate is a precursor for um for making DNA and so if you don't have that there your body will put something there from RNA a urasil instead of a a thyine and those are like nucleotides DNA build and so it basically causes these double stranded breaks”
Folate is a precursor for making DNA; without it, the body inserts uracil instead of thymine into DNA, causing double-stranded breaks.
“if you're low folate in the short term it'll cause anemia of form of anemia call which is Big cells called megastic anemia but in the long run it can cause cancer and heart disease and dementia”
Low folate in the short term can cause megaloblastic anemia, but in the long run can cause cancer, heart disease, and dementia.