Does David Sinclair recommend Quercetin?
Yes — David Sinclair has directly recommended Quercetin.
Published research rates it weak evidence. Of David Sinclair's 13 tracked claims, 0 are supported or partially supported by studies on PubMed.
Evidence last reviewed May 2026
David Sinclair on Quercetin — 13 claims
“That was discovered first as a senolytic by Jim Kirkland at the Mayo Clinic who combined it with a drug called dasatinib. And together, those two molecules are potent killers of senescent cells.”
Quercetin was discovered as a senolytic by Jim Kirkland at the Mayo Clinic, who combined it with dasatinib, and together the two molecules are potent killers of senescent cells.
“we've had some randomized controlled trials with humans and quercetin. The effects are Uh reduces uh liver steatosis, a fatty liver, uh as well as other uh effects like inflammation in the body.”
Randomized controlled trials in humans with quercetin have shown it reduces liver steatosis (fatty liver) and inflammation in the body.
“That was discovered first as a senolytic by Jim Kirkland at the Mayo Clinic who combined it with a drug called dasatinib.”
Quercetin was first identified as a senolytic by Jim Kirkland at the Mayo Clinic, who combined it with the drug dasatinib.
“We've had some randomized controlled trials with humans and quercetin. The effects are Uh reduces uh liver steatosis.”
There have been randomized controlled trials with quercetin in humans, with effects including reduction of liver steatosis.
“There were others, quercetin, fisetin, which are actually now used by others for longevity. But resveratrol got most of the attention because it's found in red wine.”
Quercetin was among the original molecules identified as sirtuin activators in early yeast experiments, alongside resveratrol and fisetin.
“You can actually see that the number of senescent cells in the body goes away when you treat with quercetin and dasatinib.”
Treatment with quercetin and dasatinib visibly reduces the number of senescent cells in the body.
“those have been put into mice and into humans where they are showing really remarkable effects in treating age-related diseases.”
Quercetin combined with dasatinib has shown remarkable effects in treating age-related diseases in both mice and humans.
“the polyphenols that come from plants, quercetin, fisetin, um resveratrol, even curcumin, uh especially curcumin, they're like brick dust. They don't they don't get absorbed. They're they're they're crunchy. So, you have to mix them with something, olive oil or yogurt, so that they they get absorbed. And I know this from human clinical trials.”
Quercetin, like resveratrol and other polyphenols, is poorly absorbed and must be mixed with olive oil or yogurt to improve absorption.
“And that's what fisetin and quercetin appear to do. They do uh in the dish and in mice.”
Quercetin's senolytic effects have been demonstrated in cell cultures and in mice.
“And together, those two molecules are potent killers of senescent cells. And those have been put into mice and into humans where they are showing really remarkable effects in treating age-related diseases.”
Quercetin combined with dasatinib are potent killers of senescent cells, showing remarkable effects in treating age-related diseases in both mice and humans.
“They are what are called senolytic. Kill senescent cells... And that's what fisetin and quercetin appear to do.”
Quercetin is senolytic — it kills senescent cells.
“quercetin, uh which is a molecule related to resveratrol, which is also uh suppresses the activity of senescent cells.”
Quercetin suppresses the activity of senescent cells.
“I've added um quercetin, uh which is a molecule related to resveratrol, which is also uh suppresses the activity of senescent cells.”
David Sinclair personally takes quercetin as part of his supplement regimen.
Other supplements David Sinclair discusses
Claims are extracted from publicly available podcasts and videos, attributed to their source, and compared against PubMed research. This is educational information only — consult a healthcare provider before starting any supplement.
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