Does David Sinclair recommend Spermidine?
Yes — David Sinclair has directly recommended Spermidine.
Published research rates it moderate evidence. Of David Sinclair's 12 tracked claims, 0 are supported or partially supported by studies on PubMed.
David Sinclair on Spermidine — 12 claims
“The one that stands out for me is the one by Schwartz et al 2018. They were giving people 1.2 g per day over 3 months and there was significant enhancement of memory.”
A study by Schwartz et al. 2018 gave people 1.2 g of spermidine per day over 3 months and found significant enhancement of memory.
“There've been a number of human studies on spermidine uh particularly revolving around enhancing memory and dealing with memory loss in older Americans. That's true. We don't know a lot about aging itself but cognition has greatly improved in a number of studies.”
Human studies on spermidine have shown enhancement of memory and improvement in memory loss in older individuals.
“if you give spermidine to mice either when they're young or even late in life, they live longer and they have better heart function and other youthful capacities.”
When given to mice either when young or late in life, spermidine extends lifespan and improves heart function and other youthful capacities.
“we know it extends lifespan in yeast and flies and worms. And even mice.”
Spermidine extends lifespan in yeast, flies, worms, and mice.
“There've been a number of human studies on spermidine uh particularly revolving around enhancing memory and dealing with memory loss in older Americans. That's true. We don't know a lot about aging itself but cognition has greatly improved in a number of studies.”
Human studies on spermidine have shown that cognition, particularly memory, has greatly improved in a number of studies, though less is known about its effects on aging itself.
“The one that stands out for me is the one by Schwartz et al 2018. They were giving people 1.2 g per day over 3 months and there was significant enhancement of memory.”
In the Schwartz et al. 2018 study, giving people 1.2 g of spermidine per day over 3 months resulted in significant enhancement of memory.
“spermidine, which is also uh working on this autophagy process... One is it stimulates autophagy just like rapamycin does in the mTOR pathway.”
Spermidine works on the autophagy process, similar to rapamycin acting on the mTOR pathway.
“it also stabilizes changes to the epigenome which as you know is one of the major causes of aging.”
Spermidine also stabilizes changes to the epigenome, which is one of the major causes of aging.
“In just the last few months I've added that to my protocol and we'll have to see how my numbers look on InsideTracker.”
Sinclair has recently added spermidine to his personal supplement protocol and is testing it out to see how his numbers look.
“Spermidine. Definitely spermidine,...”
Sinclair takes spermidine daily as part of his morning supplement routine.
“You can buy it now. It's There's a a company that makes it in pure form, very low levels of gluten.”
Spermidine is available to purchase in pure form with very low levels of gluten.
“we're getting it from wheat germ. It's a lot easier. It's much more abundant. You can also find it in soy products.”
Spermidine is sourced from wheat germ and can also be found in soy products.
Other supplements David Sinclair discusses
Claims are extracted from publicly available podcasts and videos, attributed to their source, and compared against PubMed research. This is educational information only — consult a healthcare provider before starting any supplement.
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