Does Mark Hyman recommend Urolithin A?
Mark Hyman recommends Urolithin A in some contexts, but has also raised cautions.
Published research rates it moderate evidence. Of Mark Hyman's 26 tracked claims, 0 are supported or partially supported by studies on PubMed.
Evidence last reviewed May 2026
Mark Hyman on Urolithin A — 26 claims
“one of the most promising compounds to do this is something called urolithin A”
Urolithin A is one of the most promising compounds for targeting mitochondrial decline for healthy aging.
“one of the most promising compounds to do this is something called urolithin A”
Urolithin A is one of the most promising compounds for targeting mitochondrial decline for healthy aging.
“A new clinical trial in healthy, middle-aged adults found that just 4 weeks of supplementing with 1,000 mg of urolithin A, which is what I take every day, led to a more youthful immune profile. T cells became more responsive, the immune system got better at clearing threats, markers of inflammation, they all went down, all while mitochondrial energy production improved across the board.”
A new clinical trial found that 4 weeks of supplementing with 1,000 mg of urolithin A daily led to a more youthful immune profile in healthy middle-aged adults, with T cells becoming more responsive, the immune system getting better at clearing threats, markers of inflammation going down, and mitochondrial energy production improving.
“A new clinical trial in healthy, middle-aged adults found that just 4 weeks of supplementing with 1,000 mg of urolithin A, which is what I take every day, led to a more youthful immune profile. T cells became more responsive, the immune system got better at clearing threats, markers of inflammation, they all went down, all while mitochondrial energy production improved across the board.”
A new clinical trial found that 4 weeks of supplementing with 1,000 mg of urolithin A daily led to a more youthful immune profile in healthy middle-aged adults, with T cells becoming more responsive, the immune system getting better at clearing threats, markers of inflammation going down, and mitochondrial energy production improving.
“science has already shown that urolithin A supports muscle and skin health”
Urolithin A supports muscle and skin health, as already shown by science.
“science has already shown that urolithin A supports muscle and skin health”
Urolithin A supports muscle and skin health, as already shown by science.
“urolithin A that is the result of a input from a pro a food product from a from a plant from a pomegranate juice that gets transformed by a fraction of us into a product that has immense benefit. So, company was founded based on this. Amazentis actually sells this product.”
Urolithin A, derived from pomegranate juice via microbiome transformation, has immense benefit, and a company (Amazentis) was founded to sell it as a product.
“urolithin A that is the result of a input from a pro a food product from a from a plant from a pomegranate juice that gets transformed by a fraction of us into a product that has immense benefit. So, company was founded based on this. Amazentis actually sells this product.”
Urolithin A, derived from pomegranate juice via microbiome transformation, has immense benefit, and a company (Amazentis) was founded to sell it as a product.
“not all urolithin A is clinically tested and third-party certified”
Not all urolithin A products are clinically tested and third-party certified, which is a reason to choose Mitopure specifically.
“not all urolithin A is clinically tested and third-party certified”
Not all urolithin A products are clinically tested and third-party certified, which is a reason to choose Mitopure specifically.
“it's a natural molecule that your body can make when you have the right gut bacteria to convert compounds found in foods like pomegranate and walnuts”
Urolithin A is a natural molecule the body can produce when the right gut bacteria convert compounds found in foods like pomegranate and walnuts.
“only 30 to 40% of people can produce urolithin A naturally”
Only 30 to 40% of people can produce urolithin A naturally.
“these compounds are not acting by themselves. They are actually metabolized by your microbiome. And that's really And the products of that is made by by your microbiome is is called urolithin A.”
Ellagitannins from pomegranate are not acting by themselves; they are metabolized by the gut microbiome, and the product of that metabolism is urolithin A.
“only 30 to 40% of people can produce urolithin A naturally”
Only 30 to 40% of people can produce urolithin A naturally.
“urolithin A has this remarkable ability to activate mitophagy. Mitophagy is not sort of the as the term implies, it's eating mitochondria, but it doesn't eat them discriminately. It eats the old, defective mitochondria”
Urolithin A activates mitophagy, which selectively removes old and defective mitochondria.
“it's a natural molecule that your body can make when you have the right gut bacteria to convert compounds found in foods like pomegranate and walnuts”
Urolithin A is a natural molecule the body can produce when the right gut bacteria convert compounds found in foods like pomegranate and walnuts.
“we don't make, for example, one of these postbiotics called urolithin A, so we make it from pomegranate or other ellagitannins that are in, you know, walnuts or berries or whatever.”
Urolithin A is a postbiotic that humans do not make themselves; it is produced by gut microbiome metabolism of ellagitannins found in pomegranate, walnuts, berries, and similar foods.
“urolithin A has this remarkable ability to activate mitophagy. Mitophagy is not sort of the as the term implies, it's eating mitochondria, but it doesn't eat them discriminately. It eats the old, defective mitochondria”
Urolithin A activates mitophagy, which selectively removes old and defective mitochondria.
“only about 35% of people whose microbiome cuz remember, all of our microbiomes are different. And some 60% of people's microbiome is not able to make that conversion.”
Only about 35% of people have a microbiome capable of converting ellagitannins into urolithin A; approximately 60% of people's microbiomes cannot make that conversion.
“we don't make, for example, one of these postbiotics called urolithin A, so we make it from pomegranate or other ellagitannins that are in, you know, walnuts or berries or whatever.”
Urolithin A is a postbiotic that humans do not make themselves; it is produced by gut microbiome metabolism of ellagitannins found in pomegranate, walnuts, berries, and similar foods.
Other supplements Mark Hyman discusses
Claims are extracted from publicly available podcasts and videos, attributed to their source, and compared against PubMed research. This is educational information only — consult a healthcare provider before starting any supplement.
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